The Preliminary Study of Effects of Tolfenamic Acid on Cell Proliferation, Cell Apoptosis, and Intracellular Collagen Deposition in Keloid Fibroblasts In Vitro
Joint Authors
Chen, Ji
Chen, Yanfang
Yi, Dan
Newman, Mackenzie S.
Simman, Richard
Source
Dermatology Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Keloid scarring is a fibroproliferative disorder due to the accumulation of collagen type I.
Tolfenamic acid (TA), a nonsteroidal anti-inflammatory drug, has been found to potentially affect the synthesis of collagen in rats.
In this preliminary study, we aimed to test the effects of TA on cell proliferation, cell apoptosis, and the deposition of intracellular collagen in keloid fibroblasts.
Normal fibroblasts (NFs) and keloid fibroblasts (KFs) were obtained from human dermis tissue.
Within the dose range 10−3–10−6 M and exposure times 24 h, 48 h, and 72 h, we found that 0.55 × 10−3 M TA at 48 h exposure exhibited significantly decreased cell proliferation in both NFs and KFs.
Under these experimental conditions, we demonstrated that (1) TA treatment induced a remarkable apoptotic rate in KFs compared to NFs; (2) TA treatment reduced collagen production in KFs versus NFs; (3) TA treatment decreased collagen type I expression in KFs comparing to that of NFs.
In summary, our data suggest that TA decreases cell proliferation, induces cell apoptosis, and inhibits collagen accumulation in KFs.
American Psychological Association (APA)
Yi, Dan& Chen, Ji& Newman, Mackenzie S.& Chen, Yanfang& Simman, Richard. 2014. The Preliminary Study of Effects of Tolfenamic Acid on Cell Proliferation, Cell Apoptosis, and Intracellular Collagen Deposition in Keloid Fibroblasts In Vitro. Dermatology Research and Practice،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035086
Modern Language Association (MLA)
Yi, Dan…[et al.]. The Preliminary Study of Effects of Tolfenamic Acid on Cell Proliferation, Cell Apoptosis, and Intracellular Collagen Deposition in Keloid Fibroblasts In Vitro. Dermatology Research and Practice No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035086
American Medical Association (AMA)
Yi, Dan& Chen, Ji& Newman, Mackenzie S.& Chen, Yanfang& Simman, Richard. The Preliminary Study of Effects of Tolfenamic Acid on Cell Proliferation, Cell Apoptosis, and Intracellular Collagen Deposition in Keloid Fibroblasts In Vitro. Dermatology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035086
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035086