Protective Effect of Tetramethylpyrazine on Myocardial Ischemia-Reperfusion Injury
Joint Authors
Qian, Weidong
Fang, Zhuyuan
Lu, Haiting
Wang, Zhensheng
Xiong, Xingjiang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Myocardial ischemia-reperfusion injury (MIRI) is a common pathological and physiological phenomenon.
Tetramethylpyrazine is the extract of the traditional Chinese medicine Chuanxiong, which can exert protective effects on MIRI in multiple ways.
This paper reviewed the current research progress and evidence about the cardiovascular effects of tetramethylpyrazine, which included protecting mitochondria and improving energy metabolism, scavenging oxygen free radicals (OFRs) to inhibit lipid peroxidation, attenuating calcium (Ca2+) overload and maintaining Ca2+ homeostasis in cells, inhibiting apoptosis and protecting myocardial cells, interfering with the inflammatory reaction and mitigating cell injury, interfering with cell signaling pathways, and improving function of endothelial cells and protecting myocardial cells.
However, further rigorously designed randomized controlled trials are warranted.
American Psychological Association (APA)
Qian, Weidong& Xiong, Xingjiang& Fang, Zhuyuan& Lu, Haiting& Wang, Zhensheng. 2014. Protective Effect of Tetramethylpyrazine on Myocardial Ischemia-Reperfusion Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035093
Modern Language Association (MLA)
Qian, Weidong…[et al.]. Protective Effect of Tetramethylpyrazine on Myocardial Ischemia-Reperfusion Injury. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1035093
American Medical Association (AMA)
Qian, Weidong& Xiong, Xingjiang& Fang, Zhuyuan& Lu, Haiting& Wang, Zhensheng. Protective Effect of Tetramethylpyrazine on Myocardial Ischemia-Reperfusion Injury. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035093
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035093