Protective Effect of Sundarban Honey against Acetaminophen-Induced Acute Hepatonephrotoxicity in Rats
Joint Authors
Afroz, Rizwana
Tanvir, E. M.
Hossain, Md. Fuad
Khalil, Ibrahim
Parvez, Mashud
Aminul Islam, Md.
Gan, Siew Hua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Honey, a supersaturated natural product of honey bees, contains complex compounds with antioxidant properties and therefore has a wide a range of applications in both traditional and modern medicine.
In the present study, the protective effects of Sundarban honey from Bangladesh against acetaminophen- (APAP-) induced hepatotoxicity and nephrotoxicity in experimental rats were investigated.
Adult male Wistar rats were pretreated with honey (5 g/kg) for 4 weeks, followed by the induction of hepatotoxicity and nephrotoxicity via the oral administration of a single dose of APAP (2 g/kg).
Organ damage was confirmed by measuring the elevation of serum alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate transaminase (AST), total protein (TP), total bilirubin (TB), urea, creatinine, and malondialdehyde (MDA).
Histopathological alterations observed in the livers and the kidneys further confirmed oxidative damage to these tissues.
Animals pretreated with Sundarban honey showed significantly markedly reduced levels of all of the investigated parameters.
In addition, Sundarban honey ameliorated the altered hepatic and renal morphology in APAP-treated rats.
Overall, our findings indicate that Sundarban honey protects against APAP-induced acute hepatic and renal damage, which could be attributed to the honey’s antioxidant properties.
American Psychological Association (APA)
Afroz, Rizwana& Tanvir, E. M.& Hossain, Md. Fuad& Gan, Siew Hua& Parvez, Mashud& Aminul Islam, Md.…[et al.]. 2014. Protective Effect of Sundarban Honey against Acetaminophen-Induced Acute Hepatonephrotoxicity in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035102
Modern Language Association (MLA)
Afroz, Rizwana…[et al.]. Protective Effect of Sundarban Honey against Acetaminophen-Induced Acute Hepatonephrotoxicity in Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035102
American Medical Association (AMA)
Afroz, Rizwana& Tanvir, E. M.& Hossain, Md. Fuad& Gan, Siew Hua& Parvez, Mashud& Aminul Islam, Md.…[et al.]. Protective Effect of Sundarban Honey against Acetaminophen-Induced Acute Hepatonephrotoxicity in Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035102
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035102