Ameliorative Effect of Hexane Extract of Phalaris canariensis on High Fat Diet-Induced Obese and Streptozotocin-Induced Diabetic Mice
Joint Authors
Perez Gutierrez, Rosa Martha
Madrigales Ahuatzi, Diana
Horcacitas, Maria del Carmen
Garcia Baez, Efren
Cruz Victoria, Teresa
Mota-Flores, Jose Maria
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-09
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Obesity is one of the major factors to increase various disorders like diabetes.
The present paper emphasizes study related to the antiobesity effect of Phalaris canariensis seeds hexane extract (Al-H) in high-fat diet- (HFD-) induced obese CD1 mice and in streptozotocin-induced mild diabetic (MD) and severely diabetic (SD) mice.AL-H was orally administered to MD and SD mice at a dose of 400 mg/kg once a day for 30 days, and a set of biochemical parameters were studied: glucose, cholesterol, triglycerides, lipid peroxidation, liver and muscle glycogen, ALP, SGOT, SGPT, glucose-6-phosphatase, glucokinase, hexokinase, SOD, CAT, GSH, GPX activities, and the effect on insulin level.
HS-H significantly reduced the intake of food and water and body weight loss as well as levels of blood glucose, serum cholesterol, triglyceride, lipoprotein, oxidative stress, showed a protective hepatic effect, and increased HDL-cholesterol, serum insulin in diabetic mice.
The mice fed on the high-fat diet and treated with AL-H showed inhibitory activity on the lipid metabolism decreasing body weight and weight of the liver and visceral adipose tissues and cholesterol and triglycerides in the liver.
We conclude that AL-H can efficiently reduce serum glucose and inhibit insulin resistance, lipid abnormalities, and oxidative stress in MD and SD mice.
Our results demonstrate an antiobesity effect reducing lipid droplet accumulation in the liver, indicating that its therapeutic properties may be due to the interaction plant components soluble in the hexane extract, with any of the multiple targets involved in obesity and diabetes pathogenesis.
American Psychological Association (APA)
Perez Gutierrez, Rosa Martha& Madrigales Ahuatzi, Diana& Horcacitas, Maria del Carmen& Garcia Baez, Efren& Cruz Victoria, Teresa& Mota-Flores, Jose Maria. 2014. Ameliorative Effect of Hexane Extract of Phalaris canariensis on High Fat Diet-Induced Obese and Streptozotocin-Induced Diabetic Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1035103
Modern Language Association (MLA)
Perez Gutierrez, Rosa Martha…[et al.]. Ameliorative Effect of Hexane Extract of Phalaris canariensis on High Fat Diet-Induced Obese and Streptozotocin-Induced Diabetic Mice. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1035103
American Medical Association (AMA)
Perez Gutierrez, Rosa Martha& Madrigales Ahuatzi, Diana& Horcacitas, Maria del Carmen& Garcia Baez, Efren& Cruz Victoria, Teresa& Mota-Flores, Jose Maria. Ameliorative Effect of Hexane Extract of Phalaris canariensis on High Fat Diet-Induced Obese and Streptozotocin-Induced Diabetic Mice. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1035103
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035103