Neuroprotective Effects of Cuscutae Semen in a Mouse Model of Parkinson’s Disease
Joint Authors
Ye, Minsook
Lee, Seul gi
Chung, Eun Sook
Lim, Su-jin
Kim, Won Seob
Yoon, Heera
Ahn, Kwang Sung
Bae, Hyunsu
Kim, Sun Kwang
Jang, Young Pyo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Parkinson’s disease (PD) is a neurodegenerative movement disorder that is characterized by the progressive degeneration of the dopaminergic (DA) pathway.
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes damage to the DA neurons, and 1-4-methyl-4-phenylpyridinium (MPP+) causes cell death in differentiated PC12 cells that is similar to the degeneration that occurs in PD.
Moreover, MPTP treatment increases the activity of the brain’s immune cells, reactive oxygen species- (ROS-) generating processes, and glutathione peroxidase.
We recently reported that Cuscutae Semen (CS), a widely used traditional herbal medicine, increases cell viability in a yeast model of PD.
In the present study, we examined the inhibitory effect of CS on the neurotoxicity of MPTP in mice and on the MPP+-induced cell death in differentiated PC12 cells.
The MPTP-induced loss of nigral DA neurons was partly inhibited by CS-mediated decreases in ROS generation.
The activation of microglia was slightly inhibited by CS, although this effect did not reach statistical significance.
Furthermore, CS may reduce the MPP+ toxicity in PC12 cells by suppressing glutathione peroxidase activation.
These results suggest that CS may be beneficial for the treatment of neurodegenerative diseases such as PD.
American Psychological Association (APA)
Ye, Minsook& Lee, Seul gi& Chung, Eun Sook& Lim, Su-jin& Kim, Won Seob& Yoon, Heera…[et al.]. 2014. Neuroprotective Effects of Cuscutae Semen in a Mouse Model of Parkinson’s Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1035105
Modern Language Association (MLA)
Ye, Minsook…[et al.]. Neuroprotective Effects of Cuscutae Semen in a Mouse Model of Parkinson’s Disease. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1035105
American Medical Association (AMA)
Ye, Minsook& Lee, Seul gi& Chung, Eun Sook& Lim, Su-jin& Kim, Won Seob& Yoon, Heera…[et al.]. Neuroprotective Effects of Cuscutae Semen in a Mouse Model of Parkinson’s Disease. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1035105
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035105