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Glycyrrhizae Radix Methanol Extract Attenuates Methamphetamine-Induced Locomotor Sensitization and Conditioned Place Preference
Joint Authors
Lee, Bong Hyo
Zhao, ZhengLin
Yang, YuPeng
Zhang, Jie
Chang, Suchan
Zhou, FuBo
Zhao, JunChang
Zhao, RongJie
Kim, Sang Chan
Jung, Ji Yun
Yang, Chae Ha
Kim, Young Woo
Cho, Il Je
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Glycyrrhizae Radix modulates the neurochemical and locomotor alterations induced by acute psychostimulants in rodents via GABAb receptors.
This study investigated the influence of methanol extract from Glycyrrhizae Radix (MEGR) on repeated methamphetamine- (METH-) induced locomotor sensitization and conditioned place preference (CPP).
A cohort of rats was treated with METH (1 mg/kg/day) for 6 consecutive days, subjected to 6 days of withdrawal, and then challenged with the same dose of METH to induce locomotor sensitization; during the withdrawal period, the rats were administered MEGR (60 or 180 mg/kg/day).
A separate cohort of rats was treated with either METH or saline every other day for 6 days in METH-paired or saline-paired chambers, respectively, to induce CPP.
These rats were also administered MEGR (180 mg/kg) prior to every METH or CPP expression test.
Pretreatment with MEGR (60 and 180 mg/kg/day) attenuated the expression of METH-induced locomotor sensitization dose-dependently, and 180 mg/kg MEGR significantly inhibited the development and expression of METH-induced CPP.
Furthermore, administration of a selective GABAb receptor antagonist (SCH50911) prior to MEGR treatment effectively blocked the inhibitory effects of MEGR on locomotor sensitization, but not CPP.
These results suggest that Glycyrrhizae Radix blocked repeated METH-induced behavioral changes via GABAb receptors.
American Psychological Association (APA)
Zhao, ZhengLin& Kim, Young Woo& Yang, YuPeng& Zhang, Jie& Jung, Ji Yun& Chang, Suchan…[et al.]. 2014. Glycyrrhizae Radix Methanol Extract Attenuates Methamphetamine-Induced Locomotor Sensitization and Conditioned Place Preference. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035108
Modern Language Association (MLA)
Zhao, ZhengLin…[et al.]. Glycyrrhizae Radix Methanol Extract Attenuates Methamphetamine-Induced Locomotor Sensitization and Conditioned Place Preference. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1035108
American Medical Association (AMA)
Zhao, ZhengLin& Kim, Young Woo& Yang, YuPeng& Zhang, Jie& Jung, Ji Yun& Chang, Suchan…[et al.]. Glycyrrhizae Radix Methanol Extract Attenuates Methamphetamine-Induced Locomotor Sensitization and Conditioned Place Preference. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035108
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035108