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Screening for Bioactive Metabolites in Plant Extracts Modulating Glucose Uptake and Fat Accumulation
Joint Authors
Kristiansen, Karsten
El-Houri, Rime B.
Kotowska, Dorota
Olsen, Louise C. B.
Bhattacharya, Sumangala
Christensen, Lars P.
Grevsen, Kai
Oksbjerg, Niels
Færgeman, Nils
Christensen, Kathrine B.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Dichloromethane and methanol extracts of seven different food and medicinal plants were tested in a screening platform for identification of extracts with potential bioactivity related to insulin-dependent glucose uptake and fat accumulation.
The screening platform included a series of in vitro bioassays, peroxisome proliferator-activated receptor (PPAR) γ-mediated transactivation, adipocyte differentiation of 3T3-L1 cell cultures, and glucose uptake in both 3T3-L1 adipocytes and primary porcine myotubes, as well as one in vivo bioassay, fat accumulation in the nematode Caenorhabditis elegans.
We found that dichloromethane extracts of aerial parts of golden root (Rhodiola rosea) and common elder (Sambucus nigra) as well as the dichloromethane extracts of thyme (Thymus vulgaris) and carrot (Daucus carota) were able to stimulate insulin-dependent glucose uptake in both adipocytes and myotubes while weekly activating PPARγ without promoting adipocyte differentiation.
In addition, these extracts were able to decrease fat accumulation in C.
elegans.
Methanol extracts of summer savory (Satureja hortensis), common elder, and broccoli (Brassica oleracea) enhanced glucose uptake in myotubes but were not able to activate PPARγ, indicating a PPARγ-independent effect on glucose uptake.
American Psychological Association (APA)
El-Houri, Rime B.& Kotowska, Dorota& Olsen, Louise C. B.& Bhattacharya, Sumangala& Christensen, Lars P.& Grevsen, Kai…[et al.]. 2014. Screening for Bioactive Metabolites in Plant Extracts Modulating Glucose Uptake and Fat Accumulation. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035111
Modern Language Association (MLA)
El-Houri, Rime B.…[et al.]. Screening for Bioactive Metabolites in Plant Extracts Modulating Glucose Uptake and Fat Accumulation. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035111
American Medical Association (AMA)
El-Houri, Rime B.& Kotowska, Dorota& Olsen, Louise C. B.& Bhattacharya, Sumangala& Christensen, Lars P.& Grevsen, Kai…[et al.]. Screening for Bioactive Metabolites in Plant Extracts Modulating Glucose Uptake and Fat Accumulation. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035111