Effects of Chronic Electroacupuncture on Depression- and Anxiety-Like Behaviors in Rats with Chronic Neuropathic Pain
Joint Authors
Li, Qian
Yue, Na
Liu, Shen-Bin
Wang, Zhi-Fu
Mi, Wen-Li
Jiang, Jian-Wei
Yu, Jin
Wang, Yan-Qing
Wu, Gencheng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Growing evidence indicates that chronic neuropathic pain is frequently accompanied by an array of psychiatric diseases, such as depression and anxiety.
Electroacupuncture (EA), as one therapy of traditional Chinese medicine, has displayed potent antidepressant-like effects in numerous clinical studies.
The present study was designed to examine the possible effects of EA on the depressive and anxiety disorders induced by neuropathic pain.
A classic rat model of neuropathic pain was produced by chronic constriction injury (CCI) of the sciatic nerve.
EA was performed on acupoints “Bai-Hui” (GV20) and unilateral “Yang-Ling-Quan” (GB34).
The antidepressive and anxiolytic effects of EA treatment were analyzed using the forced swimming test (FST) and the elevated plus maze (EPM) test, respectively.
CCI resulted in remarkable depression- and anxiety-like behaviors, whereas the chronic EA treatment significantly improved the behavioral deficits of CCI rats.
Moreover, the phosphorylation level of the NMDA receptor type 1 (NR1) subunit was decreased in the hippocampus of CCI rats.
Intriguingly, continuous EA treatment effectively blocked this decrease in the levels of pNR1.
These results suggested that EA has antidepressive and anxiolytic effects on rats with neuropathic pain and that this might be associated with restoring the phosphorylation of NR1 in the hippocampus.
American Psychological Association (APA)
Li, Qian& Yue, Na& Liu, Shen-Bin& Wang, Zhi-Fu& Mi, Wen-Li& Jiang, Jian-Wei…[et al.]. 2014. Effects of Chronic Electroacupuncture on Depression- and Anxiety-Like Behaviors in Rats with Chronic Neuropathic Pain. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035113
Modern Language Association (MLA)
Li, Qian…[et al.]. Effects of Chronic Electroacupuncture on Depression- and Anxiety-Like Behaviors in Rats with Chronic Neuropathic Pain. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1035113
American Medical Association (AMA)
Li, Qian& Yue, Na& Liu, Shen-Bin& Wang, Zhi-Fu& Mi, Wen-Li& Jiang, Jian-Wei…[et al.]. Effects of Chronic Electroacupuncture on Depression- and Anxiety-Like Behaviors in Rats with Chronic Neuropathic Pain. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035113
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035113