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Alteration of Behavioral Changes and Hippocampus Galanin Expression in Chronic Unpredictable Mild Stress-Induced Depression Rats and Effect of Electroacupuncture Treatment
Joint Authors
Mo, Yuping
Song, Hongtao
Wang, Xin
Chen, Wanshun
Abulizi, Jiawula
Xu, Anping
Tang, Yinshan
Han, Xiangbo
Li, Zhigang
Yao, Hai-Jiang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
To explore new noninvasive treatment options for depression, this study investigated the effects of electric acupuncture (EA) for depression rat models.
Depression in rats was induced by unpredictable chronic mild stress (UCMS) combined with isolation for 21 days.
Eighteen male Sprague-Dawley rats were randomly assigned into three groups: control, model, and EA groups.
Rats were treated by EA once daily for 21 days.
The results showed that body weight and sucrose consumption were significantly increased in EA group than in the model group.
The crossing numbers and rearing numbers in the open field test significantly decreased in the model group but not in the EA group.
And EA treatments upregulated levels of hippocampus galanin (Gal) in UCMS rats back to relative normal levels.
The present study suggested that EA had antidepressant effects on UCMS model rats.
The potential antidepressant effect may be related to upregulating Gal expression in hippocampus.
American Psychological Association (APA)
Mo, Yuping& Yao, Hai-Jiang& Song, Hongtao& Wang, Xin& Chen, Wanshun& Abulizi, Jiawula…[et al.]. 2014. Alteration of Behavioral Changes and Hippocampus Galanin Expression in Chronic Unpredictable Mild Stress-Induced Depression Rats and Effect of Electroacupuncture Treatment. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035118
Modern Language Association (MLA)
Mo, Yuping…[et al.]. Alteration of Behavioral Changes and Hippocampus Galanin Expression in Chronic Unpredictable Mild Stress-Induced Depression Rats and Effect of Electroacupuncture Treatment. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035118
American Medical Association (AMA)
Mo, Yuping& Yao, Hai-Jiang& Song, Hongtao& Wang, Xin& Chen, Wanshun& Abulizi, Jiawula…[et al.]. Alteration of Behavioral Changes and Hippocampus Galanin Expression in Chronic Unpredictable Mild Stress-Induced Depression Rats and Effect of Electroacupuncture Treatment. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035118
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035118