Traditional Chinese Medicine Shuang Shen Ning Xin Attenuates Myocardial IschemiaReperfusion Injury by Preserving of Mitochondrial Function
Joint Authors
Li, Xueli
Lin, Li
Guo, Yujie
Lin, Chengren
Zhang, Cuixiang
Yang, Bin
Liu, Jianxun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
To investigate the potential cardioprotective effects of Shuang Shen Ning Xin on myocardial ischemia/reperfusion injury.
Wistar rats were treated with trimetazidine (10 mg/kg/day, ig), Shuang Shen Ning Xin (22.5, 45 mg/kg/day, ig), or saline for 5 consecutive days.
Myocardial ischemia/reperfusion injury was induced by ligation of the left anterior descending coronary artery for 40 min and reperfusion for 120 min on the last day of administration.
It is found that Shuang Shen Ning Xin pretreatment markedly decreased infarct size and serum LDH levels, and this observed protection was associated with reduced myocardial oxidative stress and cardiomyocyte apoptosis after myocardial ischemia/reperfusion injury.
In addition, further studies on mitochondrial function showed that rats treated with Shuang Shen Ning Xin displayed decreased mitochondrial swelling and cytosolic cytochrome c levels, which were accompanied by a preservation of complex I activities and inhibition of mitochondrial permeability transition.
In conclusion, the mitochondrial protective effect of Shuang Shen Ning Xin could be a new mechanism, by which Shuang Shen Ning Xin attenuates myocardial ischemia/reperfusion injury.
American Psychological Association (APA)
Li, Xueli& Liu, Jianxun& Lin, Li& Guo, Yujie& Lin, Chengren& Zhang, Cuixiang…[et al.]. 2014. Traditional Chinese Medicine Shuang Shen Ning Xin Attenuates Myocardial IschemiaReperfusion Injury by Preserving of Mitochondrial Function. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035119
Modern Language Association (MLA)
Li, Xueli…[et al.]. Traditional Chinese Medicine Shuang Shen Ning Xin Attenuates Myocardial IschemiaReperfusion Injury by Preserving of Mitochondrial Function. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1035119
American Medical Association (AMA)
Li, Xueli& Liu, Jianxun& Lin, Li& Guo, Yujie& Lin, Chengren& Zhang, Cuixiang…[et al.]. Traditional Chinese Medicine Shuang Shen Ning Xin Attenuates Myocardial IschemiaReperfusion Injury by Preserving of Mitochondrial Function. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035119
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035119