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Thirteen-Week Study of PM014 Subchronic Oral Toxicity in Rats
Joint Authors
Chung, Hwan-Suck
Lee, Hyunil
Bae, Hyunsu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
PM014 is a modified herbal formula based on Chung-Sang-Bo-Ha-Tang, which is a well-known prescription drug used for curing various inflammatory pulmonary diseases.
We previously showed that PM014 attenuated lung inflammation in a murine model of chronic obstructive pulmonary disease (COPD).
The objective of the present study was to evaluate the chronic oral toxicity of PM014 in rats.
PM014 was administered to rats orally once daily at doses of 0, 750, 1500, and 3000 mg/kg/day for 13 weeks.
The PM014 treatment did not result in any toxicologically significant changes between the control and treatment groups in body weight, clinical signs, food consumption, dermatological and serum biochemical parameters, organ weight ratio, or histopathology.
We concluded that no PM014-related toxicity was detected even at the highest doses investigated in this repeated dose oral toxicity study.
Based on our results, the no-observed-adverse-effect level (NOAEL) of PM014 was 3000 mg/kg/day in both genders.
These results might provide supportive evidence of the safety of PM014 to develop a new drug.
American Psychological Association (APA)
Chung, Hwan-Suck& Lee, Hyunil& Bae, Hyunsu. 2014. Thirteen-Week Study of PM014 Subchronic Oral Toxicity in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035125
Modern Language Association (MLA)
Chung, Hwan-Suck…[et al.]. Thirteen-Week Study of PM014 Subchronic Oral Toxicity in Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035125
American Medical Association (AMA)
Chung, Hwan-Suck& Lee, Hyunil& Bae, Hyunsu. Thirteen-Week Study of PM014 Subchronic Oral Toxicity in Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035125
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035125