A Randomized Study on Postrelapse Disease-Free Survival with Adjuvant Mistletoe versus Oral Etoposide in Osteosarcoma Patients
Joint Authors
Longhi, Alessandra
Reif, Marcus
Mariani, Erminia
Ferrari, Stefano
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Osteosarcoma is a highly malignant bone tumour.
After the second relapse, the 12-month postrelapse disease-free survival (PRDFS) rate decreases below 20%.
Oral Etoposide is often used in clinical practice after surgery as an “adjuvant” outside any protocol and with only limited evidence of improved survival.
Viscum album fermentatum Pini (Viscum) is an extract of mistletoe plants grown on pine trees for subcutaneous (sc) injection with immunomodulatory activity.
Methods.
Encouraged by preliminary findings, we conducted a study where osteosarcoma patients free from disease after second metastatic relapse were randomly assigned to Viscum sc or Oral Etoposide.
Our goal was to compare 12-month PRDFS rates with an equivalent historical control group.
Results.
Twenty patients have been enrolled, with a median age of 34 years (range 11–65) and a median follow-up time of 38.5 months (3–73).
The median PRDSF is currently 4 months (1–47) in the Etoposide and 39 months (2–73) in the Viscum group.
Patients getting Viscum reported a higher quality of life due to lower toxicity.
Conclusion.
Viscum shows promise as adjuvant treatment in prolonging PRDFS after second relapse in osteosarcoma patients.
A larger study is required to conclusively determine efficacy and immunomodulatory mechanisms of Viscum therapy in osteosarcoma patients.
American Psychological Association (APA)
Longhi, Alessandra& Reif, Marcus& Mariani, Erminia& Ferrari, Stefano. 2014. A Randomized Study on Postrelapse Disease-Free Survival with Adjuvant Mistletoe versus Oral Etoposide in Osteosarcoma Patients. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035129
Modern Language Association (MLA)
Longhi, Alessandra…[et al.]. A Randomized Study on Postrelapse Disease-Free Survival with Adjuvant Mistletoe versus Oral Etoposide in Osteosarcoma Patients. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1035129
American Medical Association (AMA)
Longhi, Alessandra& Reif, Marcus& Mariani, Erminia& Ferrari, Stefano. A Randomized Study on Postrelapse Disease-Free Survival with Adjuvant Mistletoe versus Oral Etoposide in Osteosarcoma Patients. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035129
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035129