Systematic Review and Meta-Analysis of Randomized Controlled Trials of Xingnaojing Treatment for Stroke
Joint Authors
Yang, Jingjing
Peng, Weijun
Wang, Yang
Wang, Weihao
Xu, Jianxia
Xing, Zhihua
Wang, Lexing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
Xingnaojing injection (XNJ) is a well-known traditional Chinese patent medicine (TCPM) for stroke.
The aim of this study is to assess the efficacy of XNJ for stroke including ischemic stroke, intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH).
Methods.
An extensive search was performed within using eight databases up to November 2013.
Randomized controlled trials (RCTs) on XNJ for treatment of stroke were collected.
Study selection, data extraction, quality assessment, and meta-analysis were conducted according to the Cochrane standards, and RevMan5.0 was used for meta-analysis.
Results.
This review included 13 RCTs and a total of 1,514 subjects.
The overall methodological quality was poor.
The meta-analysis showed that XNJ combined with conventional treatment was more effective for total efficacy, neurological deficit improvement, and reduction of TNF-α levels compared with those of conventional treatment alone.
Three trials reported adverse events, of these one trial reported mild impairment of kidney and liver function, whereas the other two studies failed to report specific adverse events.
Conclusion.
Despite the limitations of this review, we suggest that XNJ in combination with conventional medicines might be beneficial for the treatment of stroke.
Currently there are various methodological problems in the studies.
Therefore, high-quality, large-scale RCTs are urgently needed.
American Psychological Association (APA)
Peng, Weijun& Yang, Jingjing& Wang, Yang& Wang, Weihao& Xu, Jianxia& Wang, Lexing…[et al.]. 2014. Systematic Review and Meta-Analysis of Randomized Controlled Trials of Xingnaojing Treatment for Stroke. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035130
Modern Language Association (MLA)
Peng, Weijun…[et al.]. Systematic Review and Meta-Analysis of Randomized Controlled Trials of Xingnaojing Treatment for Stroke. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1035130
American Medical Association (AMA)
Peng, Weijun& Yang, Jingjing& Wang, Yang& Wang, Weihao& Xu, Jianxia& Wang, Lexing…[et al.]. Systematic Review and Meta-Analysis of Randomized Controlled Trials of Xingnaojing Treatment for Stroke. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035130
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035130