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Evaluation of the Effects of Vaccinium arctostaphylos L. Fruit Extract on Serum Lipids and hs-CRP Levels and Oxidative Stress in Adult Patients with Hyperlipidemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Joint Authors
Sarrafzadegan, Nizal
Asgary, Sedigheh
Soltani, Rasool
Hakimi, Mustafa
Ghanadian, Syed Mustafa
Keshvari, Mahtab
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Dyslipidemia produces atherosclerosis, which in turn results in coronary artery disease (CAD).
Atherosclerosis is being considered as an inflammatory disease.
Vaccinium arctostaphylos L.
is a plant with fruits rich in anthocyanins.
The aim of this study was to evaluate the effects of fruit extract of this plant on serum levels of lipids, hs-CRP, and malondialdehyde (MDA) as a marker of oxidative stress, in hyperlipidemic adult patients.
Methods.
In this randomized, double-blind, placebo-controlled clinical trial, 50 hyperlipidemic adult patients were randomly and equally assigned to receive either medicinal (V.
arctostaphylos fruit extract) or placebo capsules twice daily for 4 weeks.
Each medicinal capsule contained 45 ± 2 mg of anthocyanins.
Fasting serum levels of total cholesterol, TG, LDL-C, HDL-C, hs-CRP, and MDA were obtained before and after the intervention and compared.
Results.
V.
arctostaphylos fruit extract significantly reduced total cholesterol (P<0.001), LDL-C (P=0.004), TG (P<0.001), and MDA (P=0.013) compared to placebo but did not have any significant effect on HDL-C (P=0.631) and hs-CRP (P=0.190).
Conclusion.
Fruit extract of Vaccinium arctostaphylos has beneficial effects on serum lipid profile and oxidative stress in hyperlipidemic adult patients.
Therefore, it could be considered as a supplement for treatment of dyslipidemia and prevention of atherosclerosis development.
American Psychological Association (APA)
Soltani, Rasool& Hakimi, Mustafa& Asgary, Sedigheh& Ghanadian, Syed Mustafa& Keshvari, Mahtab& Sarrafzadegan, Nizal. 2014. Evaluation of the Effects of Vaccinium arctostaphylos L. Fruit Extract on Serum Lipids and hs-CRP Levels and Oxidative Stress in Adult Patients with Hyperlipidemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035132
Modern Language Association (MLA)
Soltani, Rasool…[et al.]. Evaluation of the Effects of Vaccinium arctostaphylos L. Fruit Extract on Serum Lipids and hs-CRP Levels and Oxidative Stress in Adult Patients with Hyperlipidemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1035132
American Medical Association (AMA)
Soltani, Rasool& Hakimi, Mustafa& Asgary, Sedigheh& Ghanadian, Syed Mustafa& Keshvari, Mahtab& Sarrafzadegan, Nizal. Evaluation of the Effects of Vaccinium arctostaphylos L. Fruit Extract on Serum Lipids and hs-CRP Levels and Oxidative Stress in Adult Patients with Hyperlipidemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035132
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035132