Effect of Uncaria tomentosa Extract on Apoptosis Triggered by Oxaliplatin Exposure on HT29 Cells
Joint Authors
da Rocha, João Batista Teixeira
de Oliveira, Liliane Z.
Cruz, Ivana de
Farias, J. G.
Rigo, Melânia L.
Glanzner, Werner G.
Gonçalves, Paulo Bayard D.
Cadoná, Francine C.
Franco, Luzia
Bertol, Gustavo
Brites, Patricia C.
Colpo, Elisângela
Leal, Daniela Bitencourt Rosa
Farias, Iria Luiza Gomes
Medeiros Frescura Duarte, Marta Maria
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background/Aim.
The use of herbal products as a supplement to minimize the effects of chemotherapy for cancer treatment requires further attention with respect to the activity and toxicity of chemotherapy.
Uncaria tomentosa extract, which contains oxindole alkaloids, is one of these herbal products.
The objective of this study was to evaluate whether Uncaria tomentosa extract modulates apoptosis induced by chemotherapy exposure.
Materials and Methods.
Colorectal adenocarcinoma cells (HT29 cells) were grown in the presence of oxaliplatin and/or Uncaria tomentosa extract.
Results.
The hydroalcoholic extract of Uncaria tomentosa enhanced chemotherapy-induced apoptosis, with an increase in the percentage of Annexin positive cells, an increase in caspase activities, and an increase of DNA fragments in culture of the neoplastic cells.
Moreover, antioxidant activity may be related to apoptosis.
Conclusion.
Uncaria tomentosa extract has a role for cancer patients as a complementary therapy.
Further studies evaluating these beneficial effects with other chemotherapy drugs are recommended.
American Psychological Association (APA)
de Oliveira, Liliane Z.& Farias, Iria Luiza Gomes& Rigo, Melânia L.& Glanzner, Werner G.& Gonçalves, Paulo Bayard D.& Cadoná, Francine C.…[et al.]. 2014. Effect of Uncaria tomentosa Extract on Apoptosis Triggered by Oxaliplatin Exposure on HT29 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035135
Modern Language Association (MLA)
de Oliveira, Liliane Z.…[et al.]. Effect of Uncaria tomentosa Extract on Apoptosis Triggered by Oxaliplatin Exposure on HT29 Cells. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1035135
American Medical Association (AMA)
de Oliveira, Liliane Z.& Farias, Iria Luiza Gomes& Rigo, Melânia L.& Glanzner, Werner G.& Gonçalves, Paulo Bayard D.& Cadoná, Francine C.…[et al.]. Effect of Uncaria tomentosa Extract on Apoptosis Triggered by Oxaliplatin Exposure on HT29 Cells. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035135
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035135