Treatment of Stress Urinary Incontinence by Cinnamaldehyde, the Major Constituent of the Chinese Medicinal Herb Ramulus Cinnamomi
Joint Authors
Chen, Huey-Yi
Chen, Wen-Chi
Lin, Yu-Ning
Hsieh, Wen-Tsong
Chen, Yung-Hsiang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Stress urinary incontinence (SUI) is a common disorder in middle-aged women and the elderly population.
Although surgical treatment of SUI has progressed, pharmacological therapies remain unelucidated.
We screened potential herbal medicines against SUI with an ex vivo organ bath assay.
Ramulus Cinnamomi and its major constituent cinnamaldehyde cause a high contractile force of the urethra and a low contractile force of blood vessels.
Cinnamaldehyde dose-dependently reduced lipopolysaccharide-induced nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells.
In the vaginal distension- (VD-) induced SUI model in mice, cinnamaldehyde significantly reversed the VD-induced SUI physical signs and reduced blood pressure.
Cinnamaldehyde may offer therapeutic potential against SUI without the possible side effect of hypertension.
The modulation of several SUI-related proteins including myosin, iNOS, survival motor neuron (SMN) protein, and superoxide dismutase 3 (SOD3) may play some crucial roles in the therapeutic approach against SUI.
This information may offer clues to the pathogenesis of SUI and open additional avenues for potential therapy strategies.
American Psychological Association (APA)
Chen, Yung-Hsiang& Lin, Yu-Ning& Chen, Wen-Chi& Hsieh, Wen-Tsong& Chen, Huey-Yi. 2014. Treatment of Stress Urinary Incontinence by Cinnamaldehyde, the Major Constituent of the Chinese Medicinal Herb Ramulus Cinnamomi. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035139
Modern Language Association (MLA)
Chen, Yung-Hsiang…[et al.]. Treatment of Stress Urinary Incontinence by Cinnamaldehyde, the Major Constituent of the Chinese Medicinal Herb Ramulus Cinnamomi. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1035139
American Medical Association (AMA)
Chen, Yung-Hsiang& Lin, Yu-Ning& Chen, Wen-Chi& Hsieh, Wen-Tsong& Chen, Huey-Yi. Treatment of Stress Urinary Incontinence by Cinnamaldehyde, the Major Constituent of the Chinese Medicinal Herb Ramulus Cinnamomi. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035139
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035139