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Differential Effects of Naja naja atra Venom on Immune Activity
Joint Authors
Kou, Jian-Qun
Han, Rong
Xu, Yin-Li
Ding, Xiao-Lan
Chen, Cao-Xin
Ji, Hong-Zhang
Ding, Zhi-Hui
Qin, Zheng-Hong
Wang, Shu-Zhi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Previous studies reported that Naja naja atra venom (NNAV) inhibited inflammation and adjuvant arthritis.
Here we investigated the role of NNAV in regulation of immune responses in mice.
Oral administration of NNAV to normal mice showed significant increase in natural killer cell activity, B lymphocyte proliferation stimulated by lipopolysaccharides, and antibody production in response to sheep red blood cells.
Meanwhile, NNAV markedly decreased T lymphocyte proliferation stimulated by concanavalin A, arrested the cell cycle at G0/G1 phase, and suppressed CD4 and CD8 T cell divisions.
Furthermore, NNAV inhibited the dinitrofluorobenzene-induced delayed-type hypersensitivity reaction.
This modulation of immune responses may be partly attributed to the selective increase in Th1 and Th2 cytokines (IFN-γ, IL-4) secretion and inhibition of Th17 cytokine (IL-17) production.
In dexamethasone-induced immunosuppressed mice, NNAV restored the concentration of serum IgG and IgM, while decreasing the percentage of CD4 and CD8 T-cell subsets.
These results indicate that NNAV enhances the innate and humoral immune responses while inhibiting CD4 Th17 and CD8 T cell actions, suggesting that NNAV could be a potential therapeutic agent for autoimmune diseases.
American Psychological Association (APA)
Kou, Jian-Qun& Han, Rong& Xu, Yin-Li& Ding, Xiao-Lan& Wang, Shu-Zhi& Chen, Cao-Xin…[et al.]. 2014. Differential Effects of Naja naja atra Venom on Immune Activity. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1035145
Modern Language Association (MLA)
Kou, Jian-Qun…[et al.]. Differential Effects of Naja naja atra Venom on Immune Activity. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1035145
American Medical Association (AMA)
Kou, Jian-Qun& Han, Rong& Xu, Yin-Li& Ding, Xiao-Lan& Wang, Shu-Zhi& Chen, Cao-Xin…[et al.]. Differential Effects of Naja naja atra Venom on Immune Activity. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1035145
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035145