A Review of In Vitro and In Vivo Studies on the Efficacy of Herbal Medicines for Primary Dysmenorrhea
Joint Authors
Hwang, Deok-Sang
Park, Kyoung-Sun
Park, Kang-In
Lee, Jin-Moo
Lee, Chang-Hoon
Jang, Jun-Bock
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Purpose.
Primary dysmenorrhea (PD) is a common gynecological complaint among adolescent girls and women of reproductive age.
This study aims to review the findings of published articles on the in vitro and in vivo efficacy of herbal medicines for PD.
Methods.
In vitro and in vivo studies of herbal compounds, individual herbal extracts, or herbal formula decoctions published from their inception to April 2014 were included in this review.
Results.
A total of 18 studies involving herbal medicines exhibited their inhibitory effect on PD.
The majority of in vitro studies investigated the inhibition of uterine contractions.
In vivo studies suggest that herbal medicines exert a peripheral analgesic effect and a possible anti-inflammatory activity via the inhibition of prostaglandin (PG) synthesis.
The mechanisms of herbal medicines for PD are associated with PG level reduction, suppression of cyclooxygenase-2 expression, superoxide dismutase activation and malondialdehyde reduction, nitric oxide, inducible nitric oxide synthase, and nuclear factor-kappa B reduction, stimulation of somatostatin receptor, intracellular Ca2+ reduction, and recovery of phospholipid metabolism.
Conclusions.
Herbal medicines are thought to be promising sources for the development of effective therapeutic agents for PD.
Further investigations on the appropriate herbal formula and their constituents are recommended.
American Psychological Association (APA)
Park, Kyoung-Sun& Park, Kang-In& Hwang, Deok-Sang& Lee, Jin-Moo& Jang, Jun-Bock& Lee, Chang-Hoon. 2014. A Review of In Vitro and In Vivo Studies on the Efficacy of Herbal Medicines for Primary Dysmenorrhea. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1035148
Modern Language Association (MLA)
Park, Kyoung-Sun…[et al.]. A Review of In Vitro and In Vivo Studies on the Efficacy of Herbal Medicines for Primary Dysmenorrhea. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1035148
American Medical Association (AMA)
Park, Kyoung-Sun& Park, Kang-In& Hwang, Deok-Sang& Lee, Jin-Moo& Jang, Jun-Bock& Lee, Chang-Hoon. A Review of In Vitro and In Vivo Studies on the Efficacy of Herbal Medicines for Primary Dysmenorrhea. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1035148
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035148