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Anti-Inflammatory Effects of the Chinese Herbal Formula Sini Tang in Myocardial Infarction Rats
Joint Authors
Shi, Da-Zhuo
Liu, Jiangang
Peter, Karoline
Bauer, Rudolf
Zhang, Lei
Dong, Guoju
Breiteneder, Heimo
Jakowitsch, Johannes
Ma, Yan
Zhang, Da-Wu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The aim of this study was to evaluate the anti-inflammatory profiling of the Chinese herbal formula Sini Tang (SNT) in myocardial infarction (MI) rats.
SNT, a decoction consisting of four herbs: Aconitum carmichaelii, Cinnamomum cassia, Zingiber officinale, and Glycyrrhiza uralensis, was characterized as a remedy to treat syndromes corresponding to heart failure and MI in China.
Potential biomarkers, which reflect the extent of myocardial necrosis and correlate with cardiac outcomes following MI, such as atrial natriuretic peptide (ANP), high sensitivity C-reactive protein (hs-CRP), and proinflammatory cytokines such as tumor necrosis factor-α, interleukin-6, and interleukin-1β (TNF-α, IL-6, and IL-1β) were determined in plasma, serum, and in myocardial tissue of MI rats after treatment with SNT.
Our data indicate that SNT decreased significantly the levels of hs-CRP, TNF-α, IL-6, and IL-1β in MI rats.
SNT decreased the expression of ANP levels in plasma and increased the vascular active marker nitric oxide, which limits vascular inflammation.
In addition, SNT could decrease the expression of endothelin-1 levels in rat plasma post-MI.
Our data suggest that the Chinese herbal formula SNT has the potential to improve cardiac function after MI.
SNT may be a candidate for treating MI and its associated inflammatory responses.
American Psychological Association (APA)
Liu, Jiangang& Peter, Karoline& Shi, Da-Zhuo& Zhang, Lei& Dong, Guoju& Zhang, Da-Wu…[et al.]. 2014. Anti-Inflammatory Effects of the Chinese Herbal Formula Sini Tang in Myocardial Infarction Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035151
Modern Language Association (MLA)
Liu, Jiangang…[et al.]. Anti-Inflammatory Effects of the Chinese Herbal Formula Sini Tang in Myocardial Infarction Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1035151
American Medical Association (AMA)
Liu, Jiangang& Peter, Karoline& Shi, Da-Zhuo& Zhang, Lei& Dong, Guoju& Zhang, Da-Wu…[et al.]. Anti-Inflammatory Effects of the Chinese Herbal Formula Sini Tang in Myocardial Infarction Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035151
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035151