The Anxiolytic Effects of Valtrate in Rats Involves Changes of Corticosterone Levels
Joint Authors
Wang, Yan-Li
Shi, Jin-Li
Shi, Shu-Ning
Liu, Yong
Wang, Chun-Guo
Hou, Wen-Hui
Guo, Jian-You
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Valtrate is a principle compound isolated from Valeriana jatamansi Jones, which is a Traditional Chinese Medicine used to treat various mood disorders.
The aim of the present study was to investigate the anxiolytic effects of valtrate in rats.
The animals were orally administered valtrate (5, 10, and 20 g/kg daily) for 10 days and exposed to open field test (OFT) and elevated plus-maze (EPM).
Then the corticosterone levels in the rat serum were measured by enzyme-linked immunosorbent assay (ELISA).
The valtrate (10 mg/kg, p.o.) exhibited the anxiolytic effect in rats by increasing the time and entry percentage into the open arms in the EPM and the number of central entries in the OFT.
Valtrate (10 mg/kg, p.o.) significantly reduced the corticosterone level in the rat serum.
Taken together, these results suggest that the valtrate has anxiolytic activity in behavioral models that might be mediated via the function of hypothalamus-pituitary-adrenal axis.
American Psychological Association (APA)
Shi, Shu-Ning& Shi, Jin-Li& Liu, Yong& Wang, Yan-Li& Wang, Chun-Guo& Hou, Wen-Hui…[et al.]. 2014. The Anxiolytic Effects of Valtrate in Rats Involves Changes of Corticosterone Levels. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035154
Modern Language Association (MLA)
Shi, Shu-Ning…[et al.]. The Anxiolytic Effects of Valtrate in Rats Involves Changes of Corticosterone Levels. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035154
American Medical Association (AMA)
Shi, Shu-Ning& Shi, Jin-Li& Liu, Yong& Wang, Yan-Li& Wang, Chun-Guo& Hou, Wen-Hui…[et al.]. The Anxiolytic Effects of Valtrate in Rats Involves Changes of Corticosterone Levels. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035154
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035154