Danggui-Shaoyao-San Improves Learning and Memory in Female SAMP8 via Modulation of Estradiol
Joint Authors
Huang, Yan
Hu, Zeng-yao
Yuan, Hui
Shu, Lei
Liu, Gang
Qiao, Shan-yi
Sun, Lei
Zhang, Yong-xiang
Zhou, Wenxia
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Previous studies showed that Danggui-Shaoyao-San (DSS), a traditional Chinese medicinal prescription, could alleviate cognitive dysfunction of Alzheimer’s disease (AD) patients.
However, the mechanisms remain unclear; we have now examined the effect of DSS on SAMP8 and elucidated the possible mechanism.
Animals were treated with DSS for 2 months, and step-down test and Morris water maze (MWM) test were used to evaluated cognitive abilities.
The estradiol (E2), NO, and glycine in blood plasma or in hippocampus were detected to explore the possible mechanisms.
The latency of SAMP8 in step-down test was shorter than that of age-matched SAMR1, and DSS increased the latency especially in female animals.
In MWM test, we got similar results; SAMP8 spent more time to find the platform, and DSS decreased the time before finding the platform, with little effect on swim velocity, during the training sessions.
During test session, DSS increased the time spent in target quadrant especially in female SAMP8.
In female SAMP8, plasma E2, NO, and glycine were elevated in plasma or hippocampus tissue.
In conclusion, DSS could ameliorate deterioration of cognition in SAMP8, especially in female animals.
Increasing E2, NO, and glycine might contribute to the cognitive improvement effect of DSS in female SAMP8.
American Psychological Association (APA)
Huang, Yan& Hu, Zeng-yao& Yuan, Hui& Shu, Lei& Liu, Gang& Qiao, Shan-yi…[et al.]. 2014. Danggui-Shaoyao-San Improves Learning and Memory in Female SAMP8 via Modulation of Estradiol. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035155
Modern Language Association (MLA)
Huang, Yan…[et al.]. Danggui-Shaoyao-San Improves Learning and Memory in Female SAMP8 via Modulation of Estradiol. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1035155
American Medical Association (AMA)
Huang, Yan& Hu, Zeng-yao& Yuan, Hui& Shu, Lei& Liu, Gang& Qiao, Shan-yi…[et al.]. Danggui-Shaoyao-San Improves Learning and Memory in Female SAMP8 via Modulation of Estradiol. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035155