KCHO-1, a Novel Antineuroinflammatory Agent, Inhibits Lipopolysaccharide-Induced Neuroinflammatory Responses through Nrf2-Mediated Heme Oxygenase-1 Expression in Mouse BV2 Microglia Cells
Joint Authors
Kim, Youn-Chul
Oh, Hyun Cheol
Lee, Jun Kyoung
Son, Ilhong
Lee, Dong-Sung
Ko, Wonmin
Yoon, Chi-Su
Kim, Dong-Cheol
Yun, Jinju
Jun, Ki-Young
Kim, Dong-Woung
Song, Bong-Keun
Choi, Seulah
Kim, Sungchul
Jang, Jun-Hyeog
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The brain is vulnerable to oxidative stress and inflammation that can occur as a result of aging or neurodegenerative diseases.
Our work has sought to identify natural products that regulate heme oxygenase (HO)-1 and to determine their mechanism of action in neurodegenerative diseases.
KCHO-1 is a novel herbal therapeutic containing 30% ethanol (EtOH) extracts from nine plants.
In this study, we investigated the antineuroinflammatory effects of KCHO-1 in lipopolysaccharide- (LPS-) treated mouse BV2 microglia.
KCHO-1 inhibited the protein expression of inducible nitric oxide synthase (iNOS), iNOS-derived nitric oxide (NO), cyclooxygenase- (COX-) 2, and COX-2-derived prostaglandin E2 (PGE2) in LPS-stimulated BV2 microglia.
It also reduced tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6 production.
This effect was correlated with the suppression of inhibitor of nuclear factor kappa B-α (IκB-α) phosphorylation and degradation and nuclear factor kappa B (NF-κB) translocation and DNA binding.
Additionally, KCHO-1 upregulated HO-1 expression by promoting nuclear translocation of nuclear factor E2-related factor 2 (Nrf2) in mouse BV2 microglia.
Tin protoporphyrin (SnPP), an HO activity inhibitor, was used to verify the inhibitory effects of KCHO-1 on proinflammatory mediators and proteins associated with HO-1 expression.
Our data suggest that KCHO-1 has therapeutic potential in neurodegenerative diseases caused by neuroinflammation.
American Psychological Association (APA)
Lee, Dong-Sung& Ko, Wonmin& Yoon, Chi-Su& Kim, Dong-Cheol& Yun, Jinju& Lee, Jun Kyoung…[et al.]. 2014. KCHO-1, a Novel Antineuroinflammatory Agent, Inhibits Lipopolysaccharide-Induced Neuroinflammatory Responses through Nrf2-Mediated Heme Oxygenase-1 Expression in Mouse BV2 Microglia Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1035166
Modern Language Association (MLA)
Lee, Dong-Sung…[et al.]. KCHO-1, a Novel Antineuroinflammatory Agent, Inhibits Lipopolysaccharide-Induced Neuroinflammatory Responses through Nrf2-Mediated Heme Oxygenase-1 Expression in Mouse BV2 Microglia Cells. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1035166
American Medical Association (AMA)
Lee, Dong-Sung& Ko, Wonmin& Yoon, Chi-Su& Kim, Dong-Cheol& Yun, Jinju& Lee, Jun Kyoung…[et al.]. KCHO-1, a Novel Antineuroinflammatory Agent, Inhibits Lipopolysaccharide-Induced Neuroinflammatory Responses through Nrf2-Mediated Heme Oxygenase-1 Expression in Mouse BV2 Microglia Cells. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1035166
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035166