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Subacute Oral Toxicity of Yukmijiwhang-Tang in Crl:CD Sprague-Dawley Rats and Its Cytotoxicity
Joint Authors
Seo, Chang-Seob
Huh, Jung-Im
Shin, Hyeun-Kyoo
Jeong, Soo-Jin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
The traditional herbal formula Yukmijiwhang-tang (YMJ) consists of six medicinal herbs and has been used to treat dysuria, diabetic mellitus, and neurosis in Korea, China, and Japan.
Here we report safety information on its subacute toxicity and the cytotoxicity.
Methods.
YMJ extract was administered to SD rats at various dosages for 4 weeks.
We monitored clinical signs, mortality, body and organ weights, food intake, and hematological and serum biochemistry factors.
For cytotoxicity testing, each cell line was treated with various concentrations of YMJ for 24 h.
Results.
YMJ treatment had no significant effects on changes in clinical signs, body weight, or food intake in male or female rats.
In male rats, YMJ treatment decreased the absolute weights of the epididymides and serum Na levels.
In female rats, YMJ significantly reduced the prothrombin time (PT) and serum creatine level.
However, the changes were not severe and were considered to be in the normal physiological range for rats.
The no-observed-adverse-effect-level (NOAEL) was estimated to be 2000 mg/kg/day.
YMJ extract did not exert any cytotoxicity against 23 tested cell lines.
Conclusions.
Our data provide scientific evidence on the safety of YMJ for potential development as a prescription drug.
American Psychological Association (APA)
Jeong, Soo-Jin& Seo, Chang-Seob& Huh, Jung-Im& Shin, Hyeun-Kyoo. 2014. Subacute Oral Toxicity of Yukmijiwhang-Tang in Crl:CD Sprague-Dawley Rats and Its Cytotoxicity. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1035167
Modern Language Association (MLA)
Jeong, Soo-Jin…[et al.]. Subacute Oral Toxicity of Yukmijiwhang-Tang in Crl:CD Sprague-Dawley Rats and Its Cytotoxicity. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1035167
American Medical Association (AMA)
Jeong, Soo-Jin& Seo, Chang-Seob& Huh, Jung-Im& Shin, Hyeun-Kyoo. Subacute Oral Toxicity of Yukmijiwhang-Tang in Crl:CD Sprague-Dawley Rats and Its Cytotoxicity. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1035167
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035167