Effects and Mechanism of Bufei Yishen Formula in a Rat Chronic Obstructive Pulmonary Disease Model
Joint Authors
Ya, Li
Li, Jiansheng
Yang, Liping
Yao, Qin
Tian, Yange
Li, Suyun
Jiang, Suli
Wang, Ying
Li, Xinmin
Guo, Zheng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Bufei Yishen Formula (BYF) has been used for centuries in Asia to effectively treat patients with chronic obstructive pulmonary disease (COPD).
This study established a COPD animal model in rats, wherein three groups (control, COPD, and BYF) were used to evaluate the mechanism(s) and curative effect of BYF.
Pulmonary function and histomorphology demonstrated that BYF had an evident effect on COPD.
Gene microarray was then exploited to analyze the effects of BYF on COPD.
ClueGO analysis of differentially expressed genes indicated that BYF improved COPD by regulating expression of interleukins, myosin filament assembly components, and mitochondrial electron transport-related molecules.
Moreover, ELISA revealed that expression of several interleukins (IL1β, IL6, IL8, and IL10) was reduced in peripheral blood and bronchoalveolar lavage fluid by BYF treatment.
It was concluded that BYF has therapeutic effects on COPD in rats through its effects on interleukin expression and/or secretion.
Furthermore, pharmacological or targeted expression of two differentially expressed genes, F2R and Sprik1, might be useful in novel COPD therapies.
This study provides the basis for mechanisms of BYF on COPD and new therapeutic drug targets.
American Psychological Association (APA)
Li, Jiansheng& Yang, Liping& Yao, Qin& Ya, Li& Tian, Yange& Li, Suyun…[et al.]. 2014. Effects and Mechanism of Bufei Yishen Formula in a Rat Chronic Obstructive Pulmonary Disease Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035178
Modern Language Association (MLA)
Li, Jiansheng…[et al.]. Effects and Mechanism of Bufei Yishen Formula in a Rat Chronic Obstructive Pulmonary Disease Model. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1035178
American Medical Association (AMA)
Li, Jiansheng& Yang, Liping& Yao, Qin& Ya, Li& Tian, Yange& Li, Suyun…[et al.]. Effects and Mechanism of Bufei Yishen Formula in a Rat Chronic Obstructive Pulmonary Disease Model. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035178
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035178