A Metabonomics Profiling Study on Phlegm Syndrome and Blood-Stasis Syndrome in Coronary Heart Disease Patients Using Liquid ChromatographyQuadrupole Time-of-Flight Mass Spectrometry
Joint Authors
Qiu, Xinjian
Zhao, Linlin
Wan, Ling
Li, Ruomeng
Liu, Shimi
Wang, Dongsheng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
A metabonomics approach based on liquid chromatography/quadrupole time-of-flight mass spectrometry (LC-Q-TOF/MS) was utilized to obtain potential biomarkers of coronary heart disease (CHD) patients and investigate the ZHENG types differentiation in CHD patients.
The plasma samples of 20 CHD patients with phlegm syndrome, 20 CHD patients with blood-stasis syndrome, and 16 healthy volunteers were collected in the study.
26 potential biomarkers were identified in the plasma of CHD patients and 19 differential metabolites contributed to the discrimination of phlegm syndrome and blood-stasis syndrome in CHD patients (VIP>1.5; P<0.05) which mainly involved purine metabolism, pyrimidine metabolism, amino acid metabolism, steroid biosynthesis, and arachidonic acid metabolism.
This study demonstrated that metabonomics approach based on LC-MS was useful for studying pathologic changes of CHD patients and interpreting the differentiation of ZHENG types (phlegm and blood-stasis syndrome) in traditional Chinese medicine (TCM).
American Psychological Association (APA)
Zhao, Linlin& Wan, Ling& Qiu, Xinjian& Li, Ruomeng& Liu, Shimi& Wang, Dongsheng. 2014. A Metabonomics Profiling Study on Phlegm Syndrome and Blood-Stasis Syndrome in Coronary Heart Disease Patients Using Liquid ChromatographyQuadrupole Time-of-Flight Mass Spectrometry. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035180
Modern Language Association (MLA)
Zhao, Linlin…[et al.]. A Metabonomics Profiling Study on Phlegm Syndrome and Blood-Stasis Syndrome in Coronary Heart Disease Patients Using Liquid ChromatographyQuadrupole Time-of-Flight Mass Spectrometry. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1035180
American Medical Association (AMA)
Zhao, Linlin& Wan, Ling& Qiu, Xinjian& Li, Ruomeng& Liu, Shimi& Wang, Dongsheng. A Metabonomics Profiling Study on Phlegm Syndrome and Blood-Stasis Syndrome in Coronary Heart Disease Patients Using Liquid ChromatographyQuadrupole Time-of-Flight Mass Spectrometry. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035180
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035180