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Gastrodiae Rhizoma Ethanol Extract Enhances Pentobarbital-Induced Sleeping Behaviors and Rapid Eye Movement Sleep via the Activation of GABAA-ergic Transmission in Rodents
Joint Authors
Choi, Jae Joon
Lee, Mi Kyeong
Chung, Youn Bok
Oh, Eun-Hye
Hong, Jin Tae
Oh, Ki-Wan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This research was designed to identify whether Gastrodiae Rhizoma ethanol extract (GREE) enhances pentobarbital-induced sleep via γ-aminobutyric acid- (GABA-) ergic systems and modulated sleep architectures in animals.
GREE (25, 50, and 100 mg/kg, p.o.) inhibited locomotor activity in mice, in a dose-dependent manner.
GREE not only prolonged total sleep time, but also reduced sleep latency time in pentobarbital (42 mg/kg)-treated mice.
Subhypnotic pentobarbital (28 mg/kg, i.p.) also increased the number of total sleeping animals in concomitant administration of GREE.
GREE (100 mg/kg) alone reduced the count of sleep-wake cycles in electroencephalogram.
Furthermore, GREE increased total sleep time and rapid eye movement (REM) sleep.
From the in vitro experiments, GREE increased intracellular chloride level in primary cultured cerebellar granule cells.
Protein expressions of glutamine acid decarboxylase (GAD) and GABAA receptors subtypes by western blot were increased.
Therefore, our study suggested that GREE enhances pentobarbital-induced sleeping behaviors and increased REM via the activation of GABAA-ergic transmission in rodents.
American Psychological Association (APA)
Choi, Jae Joon& Oh, Eun-Hye& Lee, Mi Kyeong& Chung, Youn Bok& Hong, Jin Tae& Oh, Ki-Wan. 2014. Gastrodiae Rhizoma Ethanol Extract Enhances Pentobarbital-Induced Sleeping Behaviors and Rapid Eye Movement Sleep via the Activation of GABAA-ergic Transmission in Rodents. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035192
Modern Language Association (MLA)
Choi, Jae Joon…[et al.]. Gastrodiae Rhizoma Ethanol Extract Enhances Pentobarbital-Induced Sleeping Behaviors and Rapid Eye Movement Sleep via the Activation of GABAA-ergic Transmission in Rodents. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1035192
American Medical Association (AMA)
Choi, Jae Joon& Oh, Eun-Hye& Lee, Mi Kyeong& Chung, Youn Bok& Hong, Jin Tae& Oh, Ki-Wan. Gastrodiae Rhizoma Ethanol Extract Enhances Pentobarbital-Induced Sleeping Behaviors and Rapid Eye Movement Sleep via the Activation of GABAA-ergic Transmission in Rodents. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035192
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035192