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PET Demonstrates Functional Recovery after Treatment by Danhong Injection in a Rat Model of Cerebral Ischemic-Reperfusion Injury
Joint Authors
Tian, Mei
Wang, Zefeng
Li, Jinhui
Zhang, Yuyan
He, Yu
Yang, Jiehong
Zhou, Huifen
Zhao, Tao
Fu, Wei
Xing, Panke
Wan, Haitong
Zhang, Hong
Song, Fahuan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study aimed to investigate neuroprotection of Danhong injection (DHI) in a rat model of cerebral ischemia using 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET).
Method.
Rats were divided into 5 groups: sham group, ischemia-reperfusion untreated (IRU) group, DHI-1 group (DHI 1 mL/kg/d), DHI-2 group (DHI 2 mL/kg/d), and DHI-4 group (DHI 4 mL/kg/d).
AII the treated groups were intraperitoneally injected with DHI daily for 14 days.
The therapeutic effects in terms of cerebral infarct volume, neurological function, and cerebral glucose metabolism were evaluated.
Expression of TNF- α and IL-1 β was detected with enzyme-linked immunosorbent assay (ELISA).
Levels of mature neuronal marker (NeuN), glial marker (GFAP), vascular density factor (vWF), and glucose transporter 1 (GLUT1) were assessed by immunohistochemistry.
Results.
Compared with the IRU group, rats treated with DHI showed dose dependent reductions in cerebral infarct volume and levels of proinflammatory cytokines, improvement of neurological function, and recovery of cerebral glucose metabolism.
Meanwhile, the significantly increased numbers of neurons, gliocytes, and vessels and the recovery of glucose utilization were found in the peri-infarct region after DHI treatment using immunohistochemical analysis.
Conclusion.
This study demonstrated the metabolic recovery after DHI treatment by micro-PET imaging with 18F-FDG and the neuroprotective effects of DHI in a rat model of cerebral ischemic-reperfusion injury.
American Psychological Association (APA)
Wang, Zefeng& Song, Fahuan& Li, Jinhui& Zhang, Yuyan& He, Yu& Yang, Jiehong…[et al.]. 2014. PET Demonstrates Functional Recovery after Treatment by Danhong Injection in a Rat Model of Cerebral Ischemic-Reperfusion Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035194
Modern Language Association (MLA)
Wang, Zefeng…[et al.]. PET Demonstrates Functional Recovery after Treatment by Danhong Injection in a Rat Model of Cerebral Ischemic-Reperfusion Injury. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1035194
American Medical Association (AMA)
Wang, Zefeng& Song, Fahuan& Li, Jinhui& Zhang, Yuyan& He, Yu& Yang, Jiehong…[et al.]. PET Demonstrates Functional Recovery after Treatment by Danhong Injection in a Rat Model of Cerebral Ischemic-Reperfusion Injury. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035194
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035194