Synergistic Effect between Cryptotanshinone and Antibiotics against Clinic Methicillin and Vancomycin-Resistant Staphylococcus aureus
Joint Authors
Cha, Jeong-Dan
Lee, Jeong-Ho
Choi, Sung-Mi
Park, Jeong Hye
Choi, Kyung Min
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-24
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Cryptotanshinone (CT), a major tanshinone of medicinal plant Salvia miltiorrhiza Bunge, demonstrated strong antibacterial activity against clinic isolated methicillin and vancomycin-resistant Staphylococcus aureus (MRSA and VRSA) in this experiment.
The CT was determined against clinic isolated MRSA 1–16 with MIC and MBC values ranging from 4 to 32 and 8 to 128 μg/mL; for MSSA 1-2 from 16 to 32 μg/mL and 64 to 128 μg/mL; for VRSA 1-2 from 2 to 4 μg/mL and 4 to 16 μg/mL, respectively.
The range of MIC50 and MIC90 of CT was 0.5–8 μg/mL and 4–64 μg/mL, respectively.
The combination effects of CT with antibiotics were synergistic (FIC index < 0.5 ) against most of tested clinic isolated MRSA, MSSA, and VRSA except additive, MRSA 4 and 16 in oxacillin, MRSA 6, 12, and 15 in ampicillin, and MRSA 6, 11, and 15 in vancomycin (FIC index < 0.75–1.0).
Furthermore, a time-kill study showed that the growth of the tested bacteria was completely attenuated after 2–6 h of treatment with the 1/2 MIC of CT, regardless of whether it was administered alone or with ampicillin, oxacillin, or vancomycin.
The results suggest that CT could be employed as a natural antibacterial agent against multidrug-resistant pathogens infection.
American Psychological Association (APA)
Cha, Jeong-Dan& Lee, Jeong-Ho& Choi, Kyung Min& Choi, Sung-Mi& Park, Jeong Hye. 2014. Synergistic Effect between Cryptotanshinone and Antibiotics against Clinic Methicillin and Vancomycin-Resistant Staphylococcus aureus. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1035200
Modern Language Association (MLA)
Cha, Jeong-Dan…[et al.]. Synergistic Effect between Cryptotanshinone and Antibiotics against Clinic Methicillin and Vancomycin-Resistant Staphylococcus aureus. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-1035200
American Medical Association (AMA)
Cha, Jeong-Dan& Lee, Jeong-Ho& Choi, Kyung Min& Choi, Sung-Mi& Park, Jeong Hye. Synergistic Effect between Cryptotanshinone and Antibiotics against Clinic Methicillin and Vancomycin-Resistant Staphylococcus aureus. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1035200
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035200