Pterostilbene on Metabolic Parameters: A Randomized, Double-Blind, and Placebo-Controlled Trial
Joint Authors
Griswold, Michael E.
Blackshear, Chad T.
Riche, Daniel M.
Sherman, Justin J.
McEwen, Corey L.
Wofford, Marion R.
Riche, Krista D.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
The purpose of this trial was to evaluate the effect of pterostilbene on metabolic parameters.
Methods.
A prospective, randomized, double-blind, and placebo-controlled study that enrolled 80 patients with a total cholesterol ≥200 mg/dL and/or LDL ≥ 100 mg/dL.
Subjects were divided into four groups: (1) pterostilbene 125 mg twice daily; (2) pterostilbene 50 mg twice daily; (3) pterostilbene 50 mg + grape extract (GE) 100 mg twice daily; (4) matching placebo twice daily for 6–8 weeks.
Endpoints included lipids, blood pressure, and weight.
Linear mixed models were used to examine and compare changes in parameters over time.
Models were adjusted for age, gender, and race.
Results.
LDL increased with pterostilbene monotherapy (17.1 mg/dL; P = 0.001 ) which was not seen with GE combination ( P = 0.47 ).
Presence of a baseline cholesterol medication appeared to attenuate LDL effects.
Both systolic (−7.8 mmHg; P < 0.01 ) and diastolic blood pressure (−7.3 mmHg; P < 0.001 ) were reduced with high dose pterostilbene.
Patients not on cholesterol medication ( n = 51 ) exhibited minor weight loss with pterostilbene (−0.62 kg/m2; P = 0.012 ).
Conclusion.
Pterostilbene increases LDL and reduces blood pressure in adults.
This trial is registered with Clinicaltrials.gov NCT01267227.
American Psychological Association (APA)
Riche, Daniel M.& Riche, Krista D.& Blackshear, Chad T.& McEwen, Corey L.& Sherman, Justin J.& Wofford, Marion R.…[et al.]. 2014. Pterostilbene on Metabolic Parameters: A Randomized, Double-Blind, and Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035203
Modern Language Association (MLA)
Riche, Daniel M.…[et al.]. Pterostilbene on Metabolic Parameters: A Randomized, Double-Blind, and Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035203
American Medical Association (AMA)
Riche, Daniel M.& Riche, Krista D.& Blackshear, Chad T.& McEwen, Corey L.& Sherman, Justin J.& Wofford, Marion R.…[et al.]. Pterostilbene on Metabolic Parameters: A Randomized, Double-Blind, and Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035203
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035203