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Effects of Danshen Ethanol Extract on the Pharmacokinetics of Fexofenadine in Healthy Volunteers
Joint Authors
Jiang, Jian
Zeng, Jin
Liu, Songcan
He, Min
Zhu, Leilei
Ye, Yujie
Miao, Ping
Shen, Shujiao
Qiu, Fu-rong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
This study investigated the effect of multidose administration of danshen ethanol extract on fexofenadine pharmacokinetics in healthy volunteers.
A sequential, open-label, two-period pharmacokinetic interaction design was used.
12 healthy male volunteers received a single oral dose of fexofenadine (60 mg) followed by danshen ethanol extract (1 g orally, three times a day) for 10 days, after which they received 1 g of the danshen extract with fexofenadine (60 mg) on the last day.
The plasma concentrations of fexofenadine was measured by LC-MS/MS.
After 10 days of the danshen extract administration, the mean AUC and C max of the fexofenadine was decreased by 37.2% and 27.4% compared with the control, respectively.
The mean clearance of fexofenadine was increased by 104.9%.
The in vitro study showed that tanshinone IIA and cryptotanshinone could induce MDR1 mRNA.
This study showed that multidose administration of danshen ethanol extract could increase oral clearance of fexofenadine.
The increased oral clearance of fexofenadine is attributable to induction of intestinal P-glycoprotein.
American Psychological Association (APA)
Qiu, Fu-rong& Zeng, Jin& Liu, Songcan& He, Min& Zhu, Leilei& Ye, Yujie…[et al.]. 2014. Effects of Danshen Ethanol Extract on the Pharmacokinetics of Fexofenadine in Healthy Volunteers. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1035212
Modern Language Association (MLA)
Qiu, Fu-rong…[et al.]. Effects of Danshen Ethanol Extract on the Pharmacokinetics of Fexofenadine in Healthy Volunteers. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1035212
American Medical Association (AMA)
Qiu, Fu-rong& Zeng, Jin& Liu, Songcan& He, Min& Zhu, Leilei& Ye, Yujie…[et al.]. Effects of Danshen Ethanol Extract on the Pharmacokinetics of Fexofenadine in Healthy Volunteers. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1035212
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035212