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Seoritae Extract Reduces Prostate Weight and Suppresses Prostate Cell Proliferation in a Rat Model of Benign Prostate Hyperplasia
Joint Authors
Ha, U-Syn
Hwang, Sung Yeoun
Kim, Sae Woong
Bae, Woong Jin
Jang, Hoon
Yuk, Seung-Mo
Han, Dong-Seok
Yoon, Shin-Hee
Han, Chang-Hee
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Seoritae is a type of black soybean that is known to have health-promoting effects due to its high isoflavone and anthocyanin contents.
We evaluated whether Seoritae extract (SE) had beneficial effects on the reduction of prostate weight in a rat model of benign prostatic hyperplasia (BPH).
BPH was induced by intramuscular injections of testosterone enanthate once a week for 5 weeks in Sprague-Dawley rats, and rats were treated with or without daily oral doses of SE during BPH induction.
After 5 weeks, the oxidative stress (superoxide dismutase and 8-hydroxy-2-deoxyguanosine), apoptosis (caspase-3), and activity of 5-alpha reductase were evaluated in the serum and prostate.
The SE treatment group showed a significant decrease in prostate weight, oxidative stress, apoptosis, and 5-alpha reductase activity compared to the nontreated BPH group.
These results show that SE is effective in decreasing the weight and proliferation of the prostate, and suggest that SE may be an effective treatment for BPH.
American Psychological Association (APA)
Jang, Hoon& Bae, Woong Jin& Yuk, Seung-Mo& Han, Dong-Seok& Ha, U-Syn& Hwang, Sung Yeoun…[et al.]. 2014. Seoritae Extract Reduces Prostate Weight and Suppresses Prostate Cell Proliferation in a Rat Model of Benign Prostate Hyperplasia. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035214
Modern Language Association (MLA)
Jang, Hoon…[et al.]. Seoritae Extract Reduces Prostate Weight and Suppresses Prostate Cell Proliferation in a Rat Model of Benign Prostate Hyperplasia. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1035214
American Medical Association (AMA)
Jang, Hoon& Bae, Woong Jin& Yuk, Seung-Mo& Han, Dong-Seok& Ha, U-Syn& Hwang, Sung Yeoun…[et al.]. Seoritae Extract Reduces Prostate Weight and Suppresses Prostate Cell Proliferation in a Rat Model of Benign Prostate Hyperplasia. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035214
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035214