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Antileishmanial Activity of Medicinal Plants Used in Endemic Areas in Northeastern Brazil
Joint Authors
Moreira, Magna S. A.
Moura, Flávia de B. Prado
Cavalcante-Silva, Luiz Henrique Agra
Dias, Thays de Lima Matos Freire
Araújo, Givanildo Bernardino de
da Matta, Carolina B. B.
Araújo-Júnior, João Xavier
de Queiroz, Aline C.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study investigates the leishmanicidal activity of five species of plants used in folk medicine in endemic areas of the state of Alagoas, Brazil.
Data were collected in the cities of Colonia Leopoldina, Novo Lino, and União dos Palmares, Alagoas state, from patients with cutaneous leishmaniasis (Leishmania amazonensis) who use medicinal plants to treat this disease.
Plants extracts were tested at a concentration of 1–100 μg/mL in all experiments, except in an assay to evaluate activity against amastigotes, when 10 μg/mL was used.
All plants extracts did not show deleterious activity to the host cell evidenced by LDH assay at 100, 10, and 1 μg/mL after 48 h of incubation.
The plants extracts Hyptis pectinata (L.) Poit, Aloe vera L., Ruta graveolens L., Pfaffia glomerata (Spreng.) Pedersen, and Chenopodium ambrosioides L.
exhibited direct activity against extracellular forms at 100 μg/mL; these extracts inhibited growth by 81.9%, 82.9%, 74.4%, 88.7%, and 87.4%, respectively, when compared with promastigotes.
The plants extracts H.
pectinata, A.
vera, and R.
graveolens also significantly diminished the number of amastigotes at 10 μg/mL, inhibiting growth by 85.0%, 40.4%, 94.2%, and 97.4%, respectively, when compared with control.
Based on these data, we conclude that the five plants exhibited considerable leishmanicidal activity.
American Psychological Association (APA)
de Queiroz, Aline C.& Dias, Thays de Lima Matos Freire& da Matta, Carolina B. B.& Cavalcante-Silva, Luiz Henrique Agra& Araújo-Júnior, João Xavier& Araújo, Givanildo Bernardino de…[et al.]. 2014. Antileishmanial Activity of Medicinal Plants Used in Endemic Areas in Northeastern Brazil. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035215
Modern Language Association (MLA)
de Queiroz, Aline C.…[et al.]. Antileishmanial Activity of Medicinal Plants Used in Endemic Areas in Northeastern Brazil. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1035215
American Medical Association (AMA)
de Queiroz, Aline C.& Dias, Thays de Lima Matos Freire& da Matta, Carolina B. B.& Cavalcante-Silva, Luiz Henrique Agra& Araújo-Júnior, João Xavier& Araújo, Givanildo Bernardino de…[et al.]. Antileishmanial Activity of Medicinal Plants Used in Endemic Areas in Northeastern Brazil. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035215
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035215