The Immunological Enhancement Activity of Propolis Flavonoids Liposome In Vitro and In Vivo
Joint Authors
Tao, Yang
Wang, Deqing
Huang, Yee
Yu, Yun
Wang, Deyun
Hu, Yuanliang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of this study was to investigate and assess the effects of propolis flavonoids liposome imposed on the immune system by comparing it to propolis flavonoids and blank liposome.
In vitro, the effects of the above drugs on macrophages were assessed by measuring the phagocytic function and cytokine production.
In vivo, the immunological adjuvant activity of propolis flavonoids liposome was compared with those of propolis flavonoids and blank liposome.
The results showed that in vitro propolis flavonoids liposome can significantly enhance the phagocytic function of macrophages and the release of IL-1β, IL-6, and IFN-γ.
In addition, subcutaneous administration of propolis flavonoids liposome with ovalbumin to mice could effectively activate the cellular and humoral immune response, including inducing higher level concentrations of IgG, IL-4, and IFN-γ in serum and the proliferation rates of splenic lymphocytes.
These findings provided valuable information regarding the immune modulatory function of propolis flavonoids liposome and indicated the possibility of use of propolis flavonoids liposome as a potential adjuvant.
American Psychological Association (APA)
Tao, Yang& Wang, Deqing& Hu, Yuanliang& Huang, Yee& Yu, Yun& Wang, Deyun. 2014. The Immunological Enhancement Activity of Propolis Flavonoids Liposome In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035220
Modern Language Association (MLA)
Tao, Yang…[et al.]. The Immunological Enhancement Activity of Propolis Flavonoids Liposome In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035220
American Medical Association (AMA)
Tao, Yang& Wang, Deqing& Hu, Yuanliang& Huang, Yee& Yu, Yun& Wang, Deyun. The Immunological Enhancement Activity of Propolis Flavonoids Liposome In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035220
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035220