Pleurotus eryngii Ameliorates Lipopolysaccharide-Induced Lung Inflammation in Mice

Abstract EN

Pleurotus eryngii (P.

eryngii) is consumed as a fresh cultivated mushroom worldwide and demonstrated to have multiple beneficial effects.

We investigated the anti-inflammatory effect of P.

eryngii in mice with acute lung injury (ALI).

Intranasal instillation of lipopolysaccharide (LPS) (10 μg/site/mouse) induced marked lung inflammation (increase in the number of inflammatory cells, protein leakage, and production of nitric oxide in bronchoalveolar lavage fluid) as well as histopathological damage in the lung, 6 h after treatment.

Mice administered heat-treated P.

eryngii (0.3–1 g/kg, p.o.

(HTPE)) 1 h before LPS challenge showed decreased pulmonary inflammation and ameliorated histopathological damage.

These results suggest that HTPE has anti-inflammatory effects against ALI.

Thus, P.

eryngii itself may also have anti-inflammatory effects and could be a beneficial food for the prevention of ALI induced by bacterial infection.