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Antitumor Effects and Biological Mechanism of Action of the Aqueous Extract of the Camptotheca acuminata Fruit in Human Endometrial Carcinoma Cells
Joint Authors
Chen, Pin-Chien
Wang, Chia-Woei
Wang, Chien-Kai
Lin, Chi-Shian
Chang, Yu-Jia
Tai, Chen-Jei
Tai, Cheng-Jeng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The aqueous extracts of the leaves and fruit of Camptotheca acuminata have long been used in traditional Chinese medicine (TCM) for treating cancer patients.
The chemotherapeutic drug, camptothecin (CPT), and related analogs were first isolated from C.
acuminata in the 1970s.
Although the antitumor effects of CPT have been characterized in recent years, the antitumor effects of aqueous extracts of C.
acuminata have not been clarified.
The aims of our current study were to determine the tumor-suppression efficiency of an aqueous extract of the fruit of C.
acuminata (AE-CA) in the human endometrial carcinoma cell lines, HEC-1A, HEC-1B, and KLE, and compare its antitumor effects with those of CPT.
Cell viability assays indicated that a dosage of AE-CA containing 0.28 mg/mL of CPT demonstrated enhanced cytotoxicity, compared with CPT treatment.
The effects of AE-CA on the induction of cell cycle arrest, the accumulation of cyclin-A2 and -B1, and the activation of caspase-3 and caspase-7 were similar to those of CPT.
Furthermore, AE-CA exhibited a synergistic effect on the cytotoxicity of cisplatin in HEC-1A and HEC-1B cells.
These results indicated that AE-CA is a potent antitumor agent and can be combined with cisplatin for the treatment of human endometrial cancer.
American Psychological Association (APA)
Lin, Chi-Shian& Chen, Pin-Chien& Wang, Chien-Kai& Wang, Chia-Woei& Chang, Yu-Jia& Tai, Cheng-Jeng…[et al.]. 2014. Antitumor Effects and Biological Mechanism of Action of the Aqueous Extract of the Camptotheca acuminata Fruit in Human Endometrial Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035279
Modern Language Association (MLA)
Lin, Chi-Shian…[et al.]. Antitumor Effects and Biological Mechanism of Action of the Aqueous Extract of the Camptotheca acuminata Fruit in Human Endometrial Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1035279
American Medical Association (AMA)
Lin, Chi-Shian& Chen, Pin-Chien& Wang, Chien-Kai& Wang, Chia-Woei& Chang, Yu-Jia& Tai, Cheng-Jeng…[et al.]. Antitumor Effects and Biological Mechanism of Action of the Aqueous Extract of the Camptotheca acuminata Fruit in Human Endometrial Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035279
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035279