Oral Administration of MBG to Modulate Immune Responses and Suppress OVA-Sensitized Allergy in a Murine Model
Joint Authors
Chen, Shiu-Nan
Chen, Sherwin
Wang, William
Wu, Yu-Sheng
Lu, Chung-Lun
Liu, Chi-Feng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Recently studies performed on mushroom isolated polysaccharides demonstrated that β-(1,3)-glucan may affect the balance of Th1/Th2 cell response.
Using ovalbumin (OVA) as a hypersensitivity inducer, we evaluated the ability of mushroom beta-glucan (MBG) in modulating Th1/Th2 cell responses in B6 mice.
As compared to the control group, administration of MBG resulted in an increase of phagocytic activities, Th1 cytokine productions, immunoglobulins including IgG2A and IgA, and a significant expression of the splenic surface markers including CD3, CD4, CD8, and F4/80.
In contrast, administration of MBG has significantly suppressed IgE and IgG1 levels and Th2 cytokines including IL-4, IL-5, and IL-6.
Histopathological observation of MBG-treated followed by OVA-treated mice showed less filtration of eosinophil in pulmonary tissue sections.
Our data suggested that administration of MBG treatments alters the natural course of the IgE-mediated hypersensitivities.
In this investigation, we realize the mushroom beta glucan alter the Th2 response toward the Th1 in the allergic, resulting in a reduction in IgE productions which played a substantive role in reducing the severity of IgE-mediated hypersensitivity.
American Psychological Association (APA)
Wu, Yu-Sheng& Chen, Sherwin& Wang, William& Lu, Chung-Lun& Liu, Chi-Feng& Chen, Shiu-Nan. 2014. Oral Administration of MBG to Modulate Immune Responses and Suppress OVA-Sensitized Allergy in a Murine Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035280
Modern Language Association (MLA)
Wu, Yu-Sheng…[et al.]. Oral Administration of MBG to Modulate Immune Responses and Suppress OVA-Sensitized Allergy in a Murine Model. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1035280
American Medical Association (AMA)
Wu, Yu-Sheng& Chen, Sherwin& Wang, William& Lu, Chung-Lun& Liu, Chi-Feng& Chen, Shiu-Nan. Oral Administration of MBG to Modulate Immune Responses and Suppress OVA-Sensitized Allergy in a Murine Model. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1035280
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035280