Time-Course of the Effects of QSYQ in Promoting Heart Function in Ameroid Constrictor-Induced Myocardial Ischemia Pigs
Joint Authors
Wang, Yong
Qiu, Qi
Lin, Yang
Guo, Shuzhen
Wang, Wei
Yang, Kexu
Suo, Wei
Li, Yu
Chuo, Wenjing
Wei, Yongxiang
Xiao, Cheng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-10
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
We aim to investigate the therapeutic effects of QSYQ on a pig myocardial ischemia (MI) model and to determine its mechanism of action.
The MI model was induced by Ameroid constriction of the left anterior descending coronary (LAD) in Ba-Ma miniature pigs.
Four groups were created: model group, digoxin group, QSYQ group, and sham-operated group.
Heart function, Ang II, CGMP, TXB2, BNP, and cTnT were evaluated before (3 weeks after operation: 0 weeks) and at 2, 4, and 8 weeks after drug administration.
After 8 weeks of administration, the pigs were sacrificed for cardiac injury measurements.
Pigs with MI showed obvious histological changes, including BNP, cTnT, Ang II, CGRP, TXB2, and ET, deregulated heart function, and increased levels of apoptotic cells in myocardial tissue.
Treatment with QSYQ improved cardiac remodeling by counteracting those events.
The administration of QSYQ was accompanied by a restoration of heart function and of the levels of Ang II, CGRP, TXB2, ET BNP, and cTnT.
In addition, QSYQ attenuated administration, reduced the apoptosis, and decreased the level of TNF-α and active caspase-3.
In conclusion, administration of QSYQ could attenuate Ameroid constrictor induced myocardial ischemia, and TNF-α and active caspase-3 seemed to be the critical potential target of QSYQ.
American Psychological Association (APA)
Qiu, Qi& Lin, Yang& Xiao, Cheng& Guo, Shuzhen& Wang, Yong& Yang, Kexu…[et al.]. 2014. Time-Course of the Effects of QSYQ in Promoting Heart Function in Ameroid Constrictor-Induced Myocardial Ischemia Pigs. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1035283
Modern Language Association (MLA)
Qiu, Qi…[et al.]. Time-Course of the Effects of QSYQ in Promoting Heart Function in Ameroid Constrictor-Induced Myocardial Ischemia Pigs. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1035283
American Medical Association (AMA)
Qiu, Qi& Lin, Yang& Xiao, Cheng& Guo, Shuzhen& Wang, Yong& Yang, Kexu…[et al.]. Time-Course of the Effects of QSYQ in Promoting Heart Function in Ameroid Constrictor-Induced Myocardial Ischemia Pigs. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1035283
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035283