![](/images/graphics-bg.png)
The Effect of Resveratrol on Surgery-Induced Epidural Fibrosis in Laminectomy Rats
Joint Authors
Zhao, Jinzhu
Sun, Peifeng
Miao, Bo
Xin, Hongmei
Xia, Guofeng
Xu, Peng
Hu, Jian
Li, Zhenfeng
Li, Jianmin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Epidural fibrosis (EF) is a common complication for the patients who underwent laminectomy.
Recently, EF is thought to cause recurrent postoperative pain after laminectomy.
Resveratrol has been shown to exert its anti-inflammatory, antifibrotic, and antiproliferative multifaceted properties.
The object of this study was to investigate the effects of resveratrol on the prevention of postlaminectomy EF formation in laminectomy rats.
A controlled double-blinded study was performed on 60 healthy adult Sprague-Dawley rats that underwent lumbar laminectomy at the L1-L2 levels.
They were divided randomly into 3 groups (1, 2, and 3) of 20 rats each—group 1: resveratrol treatment group; group 2: resveratrol dilution saline treatment group; group 3: sham group (rats underwent laminectomy without treatment).
All rats were killed 4 weeks after operation.
The Rydell score, hydroxyproline content, vimentin cells density, fibroblasts density, and inflammatory factors expressional levels all suggested better results in resveratrol group than the other two groups.
Resveratrol is able to inhibit fibroblasts proliferation, and TGF-β1 and IL-6 expressions and prevent epidural fibrosis in postlaminectomy rat.
American Psychological Association (APA)
Sun, Peifeng& Miao, Bo& Xin, Hongmei& Zhao, Jinzhu& Xia, Guofeng& Xu, Peng…[et al.]. 2014. The Effect of Resveratrol on Surgery-Induced Epidural Fibrosis in Laminectomy Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035286
Modern Language Association (MLA)
Sun, Peifeng…[et al.]. The Effect of Resveratrol on Surgery-Induced Epidural Fibrosis in Laminectomy Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1035286
American Medical Association (AMA)
Sun, Peifeng& Miao, Bo& Xin, Hongmei& Zhao, Jinzhu& Xia, Guofeng& Xu, Peng…[et al.]. The Effect of Resveratrol on Surgery-Induced Epidural Fibrosis in Laminectomy Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035286
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035286