Preclinical Evaluation of Antiurolithiatic Activity of Viburnum opulus L. on Sodium Oxalate-Induced Urolithiasis Rat Model
Joint Authors
İlhan, Mert
Ergene, Burçin
Küpeli Akkol, Esra
Özbilgin, Serkan
Saltan Çitoğlu, Gülçin
Demirel, M. Ayşe
Altun, Levent
Keleş, Hikmet
Süntar, Ipek
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The aim of the present research is to evaluate the antiurolithiatic effect of the various extracts prepared from the fruits of Viburnum opulus L., in regard to its ethnobotanical record.
To induce urolithiasis, 70 mg/kg sodium oxalate was injected to the rats which were housed individually in metabolic cages.
The test materials were applied during 7 days.
Biochemical (urine and serum parameters), histopathological and antioxidant (TBARs, TSH and GSH) assays were conducted.
The urine samples were examined by light microscope for the determination of the calcium oxalate crystals.
Lyophilized juice of V.
opulus (LJVO) and lyophilized commercial juice of V.
opulus (LCJVO) exerted potential antiurolithiatic activity which was attributed to its diuretic effect along with the inhibitory action on the oxalate levels and free radical production.
We also determined the chlorogenic acid content of the LJVO by high-performance liquid chromatography (HPLC).
Chlorogenic acid was determined by using Supelcosil LC-18 ( 250 × 4.6 mm, 5 µm) column and acetonitrile: water: 0.2% o-phosphoric acid as a mobile phase.
The chlorogenic acid content of V.
opulus was found to be 0.3227 mg/mL in fruit juice.
The results obtained in this study have provided a scientific evidence for the traditional usage of V.
opulus on passing kidney stones in Turkish folk medicine.
American Psychological Association (APA)
İlhan, Mert& Ergene, Burçin& Süntar, Ipek& Özbilgin, Serkan& Saltan Çitoğlu, Gülçin& Demirel, M. Ayşe…[et al.]. 2014. Preclinical Evaluation of Antiurolithiatic Activity of Viburnum opulus L. on Sodium Oxalate-Induced Urolithiasis Rat Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035288
Modern Language Association (MLA)
İlhan, Mert…[et al.]. Preclinical Evaluation of Antiurolithiatic Activity of Viburnum opulus L. on Sodium Oxalate-Induced Urolithiasis Rat Model. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1035288
American Medical Association (AMA)
İlhan, Mert& Ergene, Burçin& Süntar, Ipek& Özbilgin, Serkan& Saltan Çitoğlu, Gülçin& Demirel, M. Ayşe…[et al.]. Preclinical Evaluation of Antiurolithiatic Activity of Viburnum opulus L. on Sodium Oxalate-Induced Urolithiasis Rat Model. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1035288
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035288