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The Traditional Kampo Medicine Tokishakuyakusan Increases Ocular Blood Flow in Healthy Subjects
Joint Authors
Nakazawa, Toru
Kaneko, Soichiro
Yaegashi, Nobuo
Takayama, Shin
Ishii, Tadashi
Shiga, Yukihiro
Kokubun, Taiki
Konno, Hideyuki
Himori, Noriko
Ryu, Morin
Kuroda, Hitoshi
Kanemura, Seiki
Numata, Takehiro
Tanaka, Junichi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of this study was to examine the effects of oral administration of kampo medical formulas on ocular blood flow (OBF).
A crossover protocol was used to randomly administer five grams of yokukansan, tokishakuyakusan (TSS), keishibukuryogan, or hachimijiogan to 13 healthy blinded subjects (mean age: 37.3 ± 12.3 years).
The mean blur rate, a quantitative OBF index obtained with laser speckle flowgraphy, was measured at the optic nerve head before and 30 minutes after administration.
Blood pressure (BP) and intraocular pressure (IOP) were also recorded.
No significant changes were observed in mean BP or IOP after the administration of any of the kampo medical formulas.
There was a significant increase in OBF 30 minutes after administration of TSS (100% to 103.6 ± 6.9%, P<0.01).
Next, TSS was administered to 19 healthy subjects (mean age: 32.0 ± 11.0 years) and OBF was measured before and 15, 30, 45, and 60 minutes after administration.
Plain water was used as a control.
OBF increased significantly after TSS administration compared to control (P<0.01) and also increased from 30 to 60 minutes after administration compared to baseline (P<0.05).
These results suggest that TSS can increase OBF without affecting BP or IOP in healthy subjects.
American Psychological Association (APA)
Takayama, Shin& Shiga, Yukihiro& Kokubun, Taiki& Konno, Hideyuki& Himori, Noriko& Ryu, Morin…[et al.]. 2014. The Traditional Kampo Medicine Tokishakuyakusan Increases Ocular Blood Flow in Healthy Subjects. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035290
Modern Language Association (MLA)
Takayama, Shin…[et al.]. The Traditional Kampo Medicine Tokishakuyakusan Increases Ocular Blood Flow in Healthy Subjects. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035290
American Medical Association (AMA)
Takayama, Shin& Shiga, Yukihiro& Kokubun, Taiki& Konno, Hideyuki& Himori, Noriko& Ryu, Morin…[et al.]. The Traditional Kampo Medicine Tokishakuyakusan Increases Ocular Blood Flow in Healthy Subjects. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035290
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035290