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Ligusticum wallichii Extract Inhibited the Expression of IL-1β after AMI in Rats
Joint Authors
Zhang, Junping
Yuan, Zhuo
Yang, Cui
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study investigated the effects of Ligusticum wallichii on IL-1β expression in myocardium and central nervous system after AMI.
AMI rat was administrated with Ligusticum wallichii extract.
A series of assays were used to detect the effects of Ligusticum wallichii extract on infarct size, left ventricular ejection fraction, expression of TLR-4, NF-κB, and IL-1β in myocardium, IL-1β expression in serum and hypothalamus, and NPY expression in hypothalamus.
We observed that Ligusticum wallichii extract improved the left ventricular ejection fraction and reduced infarct area enlargement after AMI, by inhibiting the expression of IL-1β in myocardium, serum, and hypothalamus.
Ligusticum wallichii extract reduced the expression of IL-1β in myocardium by regulating TLR4-NF-κB signaling pathway and inhibited IL-1β in hypothalamus by regulating NPY mRNA expression.
American Psychological Association (APA)
Yuan, Zhuo& Zhang, Junping& Yang, Cui. 2014. Ligusticum wallichii Extract Inhibited the Expression of IL-1β after AMI in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035306
Modern Language Association (MLA)
Yuan, Zhuo…[et al.]. Ligusticum wallichii Extract Inhibited the Expression of IL-1β after AMI in Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035306
American Medical Association (AMA)
Yuan, Zhuo& Zhang, Junping& Yang, Cui. Ligusticum wallichii Extract Inhibited the Expression of IL-1β after AMI in Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035306
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035306