Antidiabetic Effects of Carassius auratus Complex Formula in High Fat Diet Combined Streptozotocin-Induced Diabetic Mice
Joint Authors
Hsu, Cheng-chin
Lin, Hui-Hsuan
Chen, Jing-Hsien
Wang, Zhi-hong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Carassius auratus complex formula, including Carassius auratus, Rhizoma dioscoreae, Lycium chinense, and Rehmannia glutinosa Libosch, is a combination prescription of traditional Chinese medicine, which has always been used to treat diabetes mellitus in ancient China.
In this study, we provided experimental evidence for the use of Carassius auratus complex formula in the treatment of high fat diet combined streptozotocin- (STZ-) induced type 2 diabetes.
Carassius auratus complex formula aqueous extract was prepared and the effects of it on blood glucose, serum insulin, adipose tissue weight, oral glucose tolerance test (OGTT), total cholesterol, and triglyceride (TG) levels in mice were measured.
Moreover, adiponectin, TG synthesis related gene expressions, and the inhibitory effect of aldose reductase (AR) were performed to evaluate its antidiabetic effects.
After the 8-week treatment, blood glucose, insulin levels, and adipose tissue weight were significantly decreased.
OGTT and HOMA-IR index showed improved glucose tolerance.
It could also lower plasma TG, TC, and liver TG levels.
Furthermore, Carassius auratus complex formula could inhibit the activity of AR and restore adiponectin expression in serum.
Based on these findings, it is suggested that Carassius auratus complex formula possesses potent anti-diabetic effects on high fat diet combined STZ-induced diabetic mice.
American Psychological Association (APA)
Wang, Zhi-hong& Hsu, Cheng-chin& Lin, Hui-Hsuan& Chen, Jing-Hsien. 2013. Antidiabetic Effects of Carassius auratus Complex Formula in High Fat Diet Combined Streptozotocin-Induced Diabetic Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035312
Modern Language Association (MLA)
Wang, Zhi-hong…[et al.]. Antidiabetic Effects of Carassius auratus Complex Formula in High Fat Diet Combined Streptozotocin-Induced Diabetic Mice. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035312
American Medical Association (AMA)
Wang, Zhi-hong& Hsu, Cheng-chin& Lin, Hui-Hsuan& Chen, Jing-Hsien. Antidiabetic Effects of Carassius auratus Complex Formula in High Fat Diet Combined Streptozotocin-Induced Diabetic Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035312
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035312