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In Vivo Lipid Regulation Mechanism of Polygoni Multiflori Radix in High-Fat Diet Fed Rats
Joint Authors
Li, Na
Zhao, Ronghua
Yu, Jie
Lin, Pei
He, Yan Ran
Lu, Jian Mei
Gu, Wen
Wang, Wan Gen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Mechanisms of the water extracts of Polygoni Multiflori Radix (PMR) and its processed products (PMRP) on liver lipid metabolism were observed in this paper.
Aqueous extract of PMR and PMRP was given to nonalcoholic fatty liver model rats, respectively.
PMR was better in reducing the contents of very low density lipoprotein (VLDL) than PMRP and the positive control groups.
In the aspect of regulating TG, medium dose PMR reduced the activity of diacylglycerol acyltransferase (DGAT) to 1536 ± 47.69 pg/mL ( P < 0.001 ) and promoted the expression of hepatic lipase (HL) to 23.59 ± 0.2758 U/mL ( P < 0.05 ).
HL promotion ability of medium dose PMR was similar with the simvastatin positive control.
Both medium and high dose of PMR showed significant alterations in TC, which were related to the downregulation effects on hydroxyl methyl-glutaryl coenzyme A reductase (HMGCR) and upregulation effects on cholesterol 7-alpha-hydroxylase or cytochrome P450 7A (CYP7A).
Quantitative relationships research indicated that the prominent effect on inhibiting the content of HMGCR ( r = 0.756 , P < 0.05 ) was strongly positive correlated with to the TC regulation effects.
Effects of PMR on enhancing decomposition rate or reducing de novo synthesis rate of TG and TC were better than PMRP.
American Psychological Association (APA)
Lin, Pei& He, Yan Ran& Lu, Jian Mei& Li, Na& Wang, Wan Gen& Gu, Wen…[et al.]. 2014. In Vivo Lipid Regulation Mechanism of Polygoni Multiflori Radix in High-Fat Diet Fed Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035318
Modern Language Association (MLA)
Lin, Pei…[et al.]. In Vivo Lipid Regulation Mechanism of Polygoni Multiflori Radix in High-Fat Diet Fed Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035318
American Medical Association (AMA)
Lin, Pei& He, Yan Ran& Lu, Jian Mei& Li, Na& Wang, Wan Gen& Gu, Wen…[et al.]. In Vivo Lipid Regulation Mechanism of Polygoni Multiflori Radix in High-Fat Diet Fed Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035318
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035318