Electroacupuncture at Acupoints Reverses Plasma Glutamate, Lipid, and LDLVLDL in an Acute Migraine Rat Model: A 1H NMR-Based Metabolomic Study
Joint Authors
Liang, Fan-Rong
Gao, Zishan
Liu, Xuguang
Zhang, Qi
Chen, Qin
Wu, Qiaofeng
Liu, Juan
Sun, Bo
Fang, Li
Lin, Jia
Zhu, Bing-Mei
Yan, Xianzhong
Yu, Shu-Guang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-27
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Background.
The objective of this study was to identify potential biomarkers of electroacupuncture (EA) on relieving acute migraine through metabolomic study.
Methods.
EA treatments were performed on both acupoints and nonacupoints on the nitroglycerin (NTG)-induced migraine rat model.
NMR experiments and multivariate analysis were used for metabolomic analysis.
Results.
The number of head-scratching, the main ethology index of migraine rat model, was significantly increased P<0.01 after NTG injection.
The plasma metabolic profile of model group was distinct from that of the control group.
Glutamate was significantly increased P<0.01, whereas lipids were significantly decreased P<0.01 in model rats.
After EA at acupoints, the metabolic profile of model rats was normalized, with decreased glutamate P<0.05 and increased lipids P<0.01.
In contrast, EA at nonacupoints did not restore the metabolic profile, but with six metabolites significantly different from acupoints group.
Interestingly, the number of head-scratching and glutamate level were significantly decreased P<0.05 after receiving EA at both acupoints and nonacupoints.
Conclusions.
EA at acupoints may relieve acute migraine by restoring the plasma metabolic profile and plasma glutamate, while EA at nonacupoints may modestly relieve acute migraine by decreasing plasma glutamate.
American Psychological Association (APA)
Gao, Zishan& Liu, Xuguang& Yu, Shu-Guang& Zhang, Qi& Chen, Qin& Wu, Qiaofeng…[et al.]. 2014. Electroacupuncture at Acupoints Reverses Plasma Glutamate, Lipid, and LDLVLDL in an Acute Migraine Rat Model: A 1H NMR-Based Metabolomic Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1035327
Modern Language Association (MLA)
Gao, Zishan…[et al.]. Electroacupuncture at Acupoints Reverses Plasma Glutamate, Lipid, and LDLVLDL in an Acute Migraine Rat Model: A 1H NMR-Based Metabolomic Study. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1035327
American Medical Association (AMA)
Gao, Zishan& Liu, Xuguang& Yu, Shu-Guang& Zhang, Qi& Chen, Qin& Wu, Qiaofeng…[et al.]. Electroacupuncture at Acupoints Reverses Plasma Glutamate, Lipid, and LDLVLDL in an Acute Migraine Rat Model: A 1H NMR-Based Metabolomic Study. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1035327
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035327