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Characterization and Quantification of Compounds in the Hydroalcoholic Extract of the Leaves from Terminalia catappa Linn. (Combretaceae) and Their Mutagenic Activity
Joint Authors
Vilegas, Wagner
Mininel, Francisco José
Leonardo Junior, Carlos Sérgio
Espanha, Lívia Greghi
Resende, Flávia Aparecida
Varanda, Eliana Aparecida
dos Santos, Lourdes Campaner
Leite, C. Q. F.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Terminalia is a genus of Combretaceous plants widely distributed in tropical and subtropical regions.
Thus, the aim of this study was to quantify the majority compounds of the hydroalcoholic extract (7 : 3, v/v) of the leaves from T.
catappa by HPLC-PDA, chemically characterize by hyphenated techniques (HPLC-ESI-IT-MSn) and NMR, and evaluate its mutagenic activity by the Salmonella/microsome assay on S.
typhimurium strains TA98, TA97a, TA100, and TA102.
The quantification of analytes was performed using an external calibration standard.
Punicalagin is the most abundant polyphenol found in the leaves.
The presence of this compound as a mixture of anomers was confirmed using HPLC-PDA and 1H and 13C NMR.
Mutagenic activity was observed in strains TA100 and TA97a.
As the extract is a complex mixture of punicalagin, its derivatives, and several other compounds, the observed mutagenicity may be explained in part by possible synergistic interaction between the compounds present in the extract.
These studies show that mutagenic activity of T.
catappa in the Ames test can only be observed when measured at high concentrations.
However, considering the mutagenic effects observed for T.
catappa, this plant should be used cautiously for medicinal purposes.
American Psychological Association (APA)
Mininel, Francisco José& Leonardo Junior, Carlos Sérgio& Espanha, Lívia Greghi& Resende, Flávia Aparecida& Varanda, Eliana Aparecida& Leite, C. Q. F.…[et al.]. 2014. Characterization and Quantification of Compounds in the Hydroalcoholic Extract of the Leaves from Terminalia catappa Linn. (Combretaceae) and Their Mutagenic Activity. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1035330
Modern Language Association (MLA)
Mininel, Francisco José…[et al.]. Characterization and Quantification of Compounds in the Hydroalcoholic Extract of the Leaves from Terminalia catappa Linn. (Combretaceae) and Their Mutagenic Activity. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1035330
American Medical Association (AMA)
Mininel, Francisco José& Leonardo Junior, Carlos Sérgio& Espanha, Lívia Greghi& Resende, Flávia Aparecida& Varanda, Eliana Aparecida& Leite, C. Q. F.…[et al.]. Characterization and Quantification of Compounds in the Hydroalcoholic Extract of the Leaves from Terminalia catappa Linn. (Combretaceae) and Their Mutagenic Activity. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1035330
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035330