Acute and Long-Term Toxicity of Mango Leaves Extract in Mice and Rats
Joint Authors
Wang, Tao
Zhang, Yi
Li, Jian
Wu, Zhizhen
Shi, Pingping
Han, Lifeng
Guo, Lingling
Gao, Xiumei
Liu, Erwei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The acute toxicity of mango leaves extract (MLE) at the maximal dose (18.4 g/kg) was studied in ICR mice and no abnormalities were detected during the experiment.
The long-term studies at various doses of MLE (100 mg/kg, 300 mg/kg, and 900 mg/kg) in SD rats for 3 consecutive months revealed that, compared with the control group, rats in MLE treated groups showed slight body weight increase and higher fat weight; the serum TG and CHOL levels and the epididymis weight of male rats were a little higher; the serum K+ level of female rats was on the low side but the weights of liver, kidney, and adrenal gland were on the high side.
In addition to this, no other obvious abnormalities were detected.
American Psychological Association (APA)
Zhang, Yi& Li, Jian& Wu, Zhizhen& Liu, Erwei& Shi, Pingping& Han, Lifeng…[et al.]. 2014. Acute and Long-Term Toxicity of Mango Leaves Extract in Mice and Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035336
Modern Language Association (MLA)
Zhang, Yi…[et al.]. Acute and Long-Term Toxicity of Mango Leaves Extract in Mice and Rats. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035336
American Medical Association (AMA)
Zhang, Yi& Li, Jian& Wu, Zhizhen& Liu, Erwei& Shi, Pingping& Han, Lifeng…[et al.]. Acute and Long-Term Toxicity of Mango Leaves Extract in Mice and Rats. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035336
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035336