Qingkailing Suppresses the Activation of BV2 Microglial Cells by Inhibiting HypoxiaReoxygenation-Induced Inflammatory Responses
Joint Authors
Ai-Ming, Wu
Mana, Lulu
Wang, Shan
Lou, Lixia
Dong, Bin
Sun, Yikun
Yang, Shuo
Wang, Lin
Gao, Yonghong
Yan-Wei, Xing
Hai-Yan, Zhu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Qingkailing (QKL) is a well-known composite extract used in traditional Chinese medicine.
This extract has been extensively administered to treat the acute phase of cerebrovascular disease.
Our previous experiments confirmed that QKL exerts an inhibitory effect on cerebral ischemia-induced inflammatory responses.
However, whether QKL suppresses the activation of microglia, the primary resident immune cells in the brain, has yet to be determined.
In this study, BV2 microglial cells were used to validate the protective effects of QKL treatment following ischemia-reperfusion injury simulated via hypoxia/reoxygenation in vitro.
Under these conditions, high expression levels of ROS, COX-2, iNOS, and p-p38 protein were detected.
Following ischemia/reperfusion injury, QKL significantly increased the activity of BV2 cells to approximately the basal level by modulating microglial activation via inhibition of inflammatory factors, including TNF-α, COX-2, iNOS, and p-p38.
However, QKL treatment also displayed dose-dependent differences in its inhibitory effects on p38 phosphorylation and inflammatory factor expression.
American Psychological Association (APA)
Mana, Lulu& Wang, Shan& Hai-Yan, Zhu& Yan-Wei, Xing& Lou, Lixia& Ai-Ming, Wu…[et al.]. 2014. Qingkailing Suppresses the Activation of BV2 Microglial Cells by Inhibiting HypoxiaReoxygenation-Induced Inflammatory Responses. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035339
Modern Language Association (MLA)
Mana, Lulu…[et al.]. Qingkailing Suppresses the Activation of BV2 Microglial Cells by Inhibiting HypoxiaReoxygenation-Induced Inflammatory Responses. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1035339
American Medical Association (AMA)
Mana, Lulu& Wang, Shan& Hai-Yan, Zhu& Yan-Wei, Xing& Lou, Lixia& Ai-Ming, Wu…[et al.]. Qingkailing Suppresses the Activation of BV2 Microglial Cells by Inhibiting HypoxiaReoxygenation-Induced Inflammatory Responses. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1035339
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035339