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In Vivo Hypocholesterolemic Effect of MARDI Fermented Red Yeast Rice Water Extract in High Cholesterol Diet Fed Mice
Joint Authors
Beh, Boon Kee
Jaganath, InduBala
Kong, Joan
Hussin, Aminuddin bin
Jamaluddin, Anisah
Alitheen, Noorjahan Banu
Mohamad, Nurul Elyani
Long, Kamariah
Ho, Wan Yong
Yeap, Swee Keong
Mohd Yusof, Hamidah
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Fermented red yeast rice has been traditionally consumed as medication in Asian cuisine.
This study aimed to determine the in vivo hypocholesterolemic and antioxidant effects of fermented red yeast rice water extract produced using Malaysian Agricultural Research and Development Institute (MARDI) Monascus purpureus strains in mice fed with high cholesterol diet.
Absence of monacolin-k, lower level of γ-aminobutyric acid (GABA), higher content of total amino acids, and antioxidant activities were detected in MARDI fermented red yeast rice water extract (MFRYR).
In vivo MFRYR treatment on hypercholesterolemic mice recorded similar lipid lowering effect as commercial red yeast rice extract (CRYR) as it helps to reduce the elevated serum liver enzyme and increased the antioxidant levels in liver.
This effect was also associated with the upregulation of apolipoproteins-E and inhibition of Von Willebrand factor expression.
In summary, MFRYR enriched in antioxidant and amino acid without monacolin-k showed similar hypocholesterolemic effect as CRYR that was rich in monacolin-k and GABA.
American Psychological Association (APA)
Yeap, Swee Keong& Beh, Boon Kee& Kong, Joan& Ho, Wan Yong& Mohd Yusof, Hamidah& Mohamad, Nurul Elyani…[et al.]. 2014. In Vivo Hypocholesterolemic Effect of MARDI Fermented Red Yeast Rice Water Extract in High Cholesterol Diet Fed Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035342
Modern Language Association (MLA)
Yeap, Swee Keong…[et al.]. In Vivo Hypocholesterolemic Effect of MARDI Fermented Red Yeast Rice Water Extract in High Cholesterol Diet Fed Mice. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1035342
American Medical Association (AMA)
Yeap, Swee Keong& Beh, Boon Kee& Kong, Joan& Ho, Wan Yong& Mohd Yusof, Hamidah& Mohamad, Nurul Elyani…[et al.]. In Vivo Hypocholesterolemic Effect of MARDI Fermented Red Yeast Rice Water Extract in High Cholesterol Diet Fed Mice. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035342
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035342