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Topical Antinociceptive Effect of Vanillosmopsis arborea Baker on Acute Corneal Pain in Mice
Joint Authors
Leite, Gerlania O.
Silva Coutinho, Thales
de Sousa, Severino Denício Gonçalves
Sampaio, Renata Souza
Campos, Adriana Rolim
Costa, José Galberto Martins da
de Menezes, Irwin Rose Alencar
Leite, Laura H. I.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This study aimed to assess the possible topical antinociceptive activity of Vanillosmopsis arborea Baker essential oil (EOVA) and to clarify the underlying mechanism, using the acute model of chemical (eye wiping) nociception in mice.
EOVA (25 to 200 mg/kg; p.o.
and topical) evidenced significant antinociception against chemogenic pain in the test model of formalin-induced neuroinflammatory pain.
Local application of 5 M NaCl solution on the corneal surface of the eye produced a significant nociceptive behavior, characterized by eye wiping.
The number of eye wipes was counted during the first 30 s.
EOVA (25, 50, 100, and 200 mg/kg; p.o.
and topical) significantly decreased the number of eye wipes.
Naloxone, yohimbine, L-NAME, theophylline, glibenclamide, and ruthenium red had no effect on the antinociceptive effect of EOVA.
However, ondansetron, p-chlorophenylalanine methyl ester (PCPA), capsazepine, prazosin, and atropine prevented the antinociception induced by EOVA.
These results indicate the topical antinociceptive effect of EOVA and showed that 5-HT, α1, TRPV1, and central muscarinic receptors might be involved in the antinociceptive effect of EOVA in the acute corneal model of pain in mice.
American Psychological Association (APA)
Leite, Laura H. I.& Leite, Gerlania O.& Silva Coutinho, Thales& de Sousa, Severino Denício Gonçalves& Sampaio, Renata Souza& Costa, José Galberto Martins da…[et al.]. 2014. Topical Antinociceptive Effect of Vanillosmopsis arborea Baker on Acute Corneal Pain in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035343
Modern Language Association (MLA)
Leite, Laura H. I.…[et al.]. Topical Antinociceptive Effect of Vanillosmopsis arborea Baker on Acute Corneal Pain in Mice. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1035343
American Medical Association (AMA)
Leite, Laura H. I.& Leite, Gerlania O.& Silva Coutinho, Thales& de Sousa, Severino Denício Gonçalves& Sampaio, Renata Souza& Costa, José Galberto Martins da…[et al.]. Topical Antinociceptive Effect of Vanillosmopsis arborea Baker on Acute Corneal Pain in Mice. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1035343
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035343