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The Antibacterial Assay of Tectorigenin with Detergents or ATPase Inhibitors against Methicillin-Resistant Staphylococcus aureus
Joint Authors
Kim, Sung-Bae
Lee, Dong-Sung
Kim, Youn-Chul
Lee, Kuang-Shim
Gong, Ryong
Chong, Myong-Soo
Shin, Dong-Won
Joung, Dae-Ki
Kang, Ok-Hwa
Mun, Su-Hyun
Choi, Jang-Gi
Kwon, Dong-Yeul
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Tectorigenin (TTR) is an O-methylated isoflavone derived from the rhizome of Belamacanda chinensis (L.) DC.
It is known to perform a wide spectrum of biological activities such as antioxidant, anti-inflammatory, anti-tumor.
The aim of this study is to examine the mechanism of antibacterial activity of TTR against methicillin-resistant Staphylococcus aureus (MRSA).
The anti-MRSA activity of TTR was analyzed in combination assays with detergent, ATPase inhibitors, and peptidoglycan (PGN) derived from S.
aureus.
Transmission electron microscopy (TEM) was used to monitor survival characteristics and changes in S.
aureus morphology.
The MIC values of TTR against all the tested strains were 125 μg/mL.
The OD(600) of each suspension treated with a combination of Triton X-100, DCCD, and NaN3 with TTR (1/10 × MIC) had been reduced from 68% to 80%, compared to the TTR alone.
At a concentration of 125 μg/mL, PGN blocked antibacterial activity of TTR.
This study indicates that anti-MRSA action of TTR is closely related to cytoplasmic membrane permeability and ABC transporter, and PGN at 125 μg/mL directly bind to and inhibit TTR at 62.5 μg/mL.
These results can be important indication in study on antimicrobial activity mechanism against multidrug resistant strains.
American Psychological Association (APA)
Joung, Dae-Ki& Mun, Su-Hyun& Lee, Kuang-Shim& Kang, Ok-Hwa& Choi, Jang-Gi& Kim, Sung-Bae…[et al.]. 2014. The Antibacterial Assay of Tectorigenin with Detergents or ATPase Inhibitors against Methicillin-Resistant Staphylococcus aureus. Evidence-Based Complementary and Alternative Medicine،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035347
Modern Language Association (MLA)
Joung, Dae-Ki…[et al.]. The Antibacterial Assay of Tectorigenin with Detergents or ATPase Inhibitors against Methicillin-Resistant Staphylococcus aureus. Evidence-Based Complementary and Alternative Medicine No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1035347
American Medical Association (AMA)
Joung, Dae-Ki& Mun, Su-Hyun& Lee, Kuang-Shim& Kang, Ok-Hwa& Choi, Jang-Gi& Kim, Sung-Bae…[et al.]. The Antibacterial Assay of Tectorigenin with Detergents or ATPase Inhibitors against Methicillin-Resistant Staphylococcus aureus. Evidence-Based Complementary and Alternative Medicine. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1035347
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1035347